Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

Artemisinin resistance (delayed P. falciparum clearance following artemisinin-based combination therapy), is widespread across Southeast Asia but to date has not been reported in Africa(1–4). Here we genotyped the P. falciparum K13 (Pfkelch13) propeller domain, mutations in which can mediate artemis...

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Detalles Bibliográficos
Autores principales: Uwimana, Aline, Legrand, Eric, Stokes, Barbara H., Ndikumana, Jean-Louis Mangala, Warsame, Marian, Umulisa, Noella, Ngamije, Daniel, Munyaneza, Tharcisse, Mazarati, Jean-Baptiste, Munguti, Kaendi, Campagne, Pascal, Criscuolo, Alexis, Ariey, Frédéric, Murindahabi, Monique, Ringwald, Pascal, Fidock, David A., Mbituyumuremyi, Aimable, Menard, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541349/
https://www.ncbi.nlm.nih.gov/pubmed/32747827
http://dx.doi.org/10.1038/s41591-020-1005-2

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