Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation

SARS-CoV-2 is the causative agent of the COVID-19 pandemic, with 10 million infections and more than 500,000 fatalities by June 2020. To initiate infection, the SARS-CoV-2 spike (S) glycoprotein promotes attachment to the host cell surface and fusion of the viral and host membranes. Prefusion SARS-C...

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Detalles Bibliográficos
Autores principales: McCallum, Matthew, Walls, Alexandra C., Bowen, John E., Corti, Davide, Veesler, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541350/
https://www.ncbi.nlm.nih.gov/pubmed/32753755
http://dx.doi.org/10.1038/s41594-020-0483-8

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