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First‐in‐Human Studies of MW01‐6‐189WH, a Brain‐Penetrant, Antineuroinflammatory Small‐Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers

MW01‐6‐189WH (MW189) is a novel central nervous system–penetrant small‐molecule drug candidate that selectively attenuates stressor‐induced proinflammatory cytokine overproduction and is efficacious in intracerebral hemorrhage and traumatic brain injury animal models. We report first‐in‐human, rando...

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Detalles Bibliográficos
Autores principales:	Van Eldik, Linda J., Sawaki, Lumy, Bowen, Karen, Laskowitz, Daniel T., Noveck, Robert J., Hauser, Byron, Jordan, Lynn, Spears, Tracy G., Wu, Huali, Watt, Kevin, Raja, Shruti, Roy, Saktimayee M., Watterson, D. Martin, Guptill, Jeffrey T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541708/ https://www.ncbi.nlm.nih.gov/pubmed/32255549 http://dx.doi.org/10.1002/cpdd.795

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