Cargando…

Polycystin-1 Downregulation Induced Vascular Smooth Muscle Cells Phenotypic Alteration and Extracellular Matrix Remodeling in Thoracic Aortic Dissection

OBJECTIVE: Polycystin-1 (PC-1) is a protein encoded by the gene of polycystic kidney disease-1 (PKD-1). This study was designed to investigate the regulatory mechanisms of PC-1 on phenotypes of aortic vascular smooth muscle cells (VSMCs) and functions of extracellular matrix (ECM) in thoracic aortic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jing, Liu, Fei, He, Yu-bin, Zhang, Wei, Ma, Wen-rui, Xing, Jie, Wang, Li-xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541897/ https://www.ncbi.nlm.nih.gov/pubmed/33071810 http://dx.doi.org/10.3389/fphys.2020.548055

Ejemplares similares

Aortic Dissection is Associated with Reduced Polycystin-1 Expression, an Abnormality That Leads to Increased ERK Phosphorylation in Vascular Smooth Muscle Cells
por: Feng, J., et al.
Publicado: (2016)

Phenotypic Modulation of Cultured Primary Human Aortic Vascular Smooth Muscle Cells by Uremic Serum
por: Cazaña-Pérez, Violeta, et al.
Publicado: (2018)

Engineering Smooth Muscle to Understand Extracellular Matrix Remodeling and Vascular Disease
por: Yarbrough, Danielle, et al.
Publicado: (2022)

Mechanisms of Smooth Muscle Cell Differentiation Are Distinctly Altered in Thoracic Aortic Aneurysms Associated with Bicuspid or Tricuspid Aortic Valves
por: Ignatieva, Elena, et al.
Publicado: (2017)

SPINT2 is involved in the proliferation, migration and phenotypic switching of aortic smooth muscle cells: Implications for the pathogenesis of thoracic aortic dissection
por: Li, Jun, et al.
Publicado: (2023)

Markers of extracellular matrix remodeling and systemic inflammation in patients with heritable thoracic aortic diseases
por: Seim, Bjørn Edvard, et al.
Publicado: (2022)

miR‐145 attenuates phenotypic transformation of aortic vascular smooth muscle cells to prevent aortic dissection
por: Qiu, Zhi‐Huang, et al.
Publicado: (2021)

Lymphocytes influence intracranial aneurysm formation and rupture: role of extracellular matrix remodeling and phenotypic modulation of vascular smooth muscle cells
por: Sawyer, David M., et al.
Publicado: (2016)

The ion channel function of polycystin‐1 in the polycystin‐1/polycystin‐2 complex
por: Wang, Zhifei, et al.
Publicado: (2019)

Insulin Resistance Promotes the Formation of Aortic Dissection by Inducing the Phenotypic Switch of Vascular Smooth Muscle Cells
por: Zheng, Hui, et al.
Publicado: (2022)

The Role of Macrophages in Aortic Dissection
por: Wang, Xinhao, et al.
Publicado: (2020)

Downregulation of Talin-1 expression associates with increased proliferation and migration of vascular smooth muscle cells in aortic dissection
por: Wei, Xiaolong, et al.
Publicado: (2017)

Serum markers of the extracellular matrix remodeling reflect antifibrotic therapy in bile-duct ligated rats
por: Schierwagen, Robert, et al.
Publicado: (2013)

Aortic remodeling in Type B aortic dissection after thoracic endovascular aortic repair with an aortic extender cuff implantation
por: Zhang, Honggang, et al.
Publicado: (2018)

Mesenchymal Remodeling during Palatal Shelf Elevation Revealed by Extracellular Matrix and F-Actin Expression Patterns
por: Chiquet, Matthias, et al.
Publicado: (2016)

Knockdown of Ift88 in fibroblasts causes extracellular matrix remodeling and decreases conduction velocity in cardiomyocyte monolayers
por: Ernault, Auriane C., et al.
Publicado: (2022)

miR-27a regulates vascular remodeling by targeting endothelial cells' apoptosis and interaction with vascular smooth muscle cells in aortic dissection
por: Sun, Yudong, et al.
Publicado: (2019)

MicroRNA-22 Inhibits the Apoptosis of Vascular Smooth Muscle Cell by Targeting p38MAPKα in Vascular Remodeling of Aortic Dissection
por: Xiao, Yu, et al.
Publicado: (2020)

Guidance Molecules in Vascular Smooth Muscle
por: Finney, Alexandra Christine, et al.
Publicado: (2018)

Apelin expression deficiency in mice contributes to vascular stiffening by extracellular matrix remodeling of the aortic wall
por: Romier, Beatrice, et al.
Publicado: (2021)

SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling
por: Xu, Yue, et al.
Publicado: (2023)

Polycystin-2 (TRPP2) regulates primary cilium length in LLC-PK1 renal epithelial cells
por: Scarinci, Noelia, et al.
Publicado: (2022)

Inhibition of leptin-induced vascular extracellular matrix remodelling by adiponectin
por: Zhang, Zhi, et al.
Publicado: (2014)

BRG1 overexpression in smooth muscle cells promotes the development of thoracic aortic dissection
por: Yuan, Yang, et al.
Publicado: (2014)

Suppression of Eosinophil Integrins Prevents Remodeling of Airway Smooth Muscle in Asthma
por: Januskevicius, Andrius, et al.
Publicado: (2017)

Managing Thoracic Aortic Aneurysm in Patients with Bicuspid Aortic Valve Based on Aortic Root-Involvement
por: Norton, Elizabeth, et al.
Publicado: (2017)

Endothelial Transient Receptor Potential Channels and Vascular Remodeling: Extracellular Ca(2 +) Entry for Angiogenesis, Arteriogenesis and Vasculogenesis
por: Negri, Sharon, et al.
Publicado: (2020)

Vascular Smooth Muscle Cell Plasticity and Autophagy in Dissecting Aortic Aneurysms
por: Clément, Marc, et al.
Publicado: (2019)

The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections
por: Rombouts, Karlijn B., et al.
Publicado: (2021)

Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models
por: Lim, Wei-Wen, et al.
Publicado: (2020)

Commentary: Managing Thoracic Aortic Aneurysm in Patients with Bicuspid Aortic Valve Based on Aortic Root-Involvement
por: Russo, Marco, et al.
Publicado: (2017)

Case of rapid aortic remodeling after thoracic endovascular aortic repair for retrograde type A aortic dissection
por: Kikuchi, Yuta, et al.
Publicado: (2022)

Role of ADAMTS-5 in Aortic Dilatation and Extracellular Matrix Remodeling
por: Fava, Marika, et al.
Publicado: (2018)

Vascular smooth muscle ion channels in essential hypertension
por: Daghbouche-Rubio, Nuria, et al.
Publicado: (2022)

Ion channel molecular complexes in vascular smooth muscle
por: Pereira da Silva, Eric A., et al.
Publicado: (2022)

Vascular smooth muscle cells in intimal hyperplasia, an update
por: Déglise, Sébastien, et al.
Publicado: (2023)

Acute oxygen sensing by vascular smooth muscle cells
por: Moreno-Domínguez, Alejandro, et al.
Publicado: (2023)

Multiscale Modeling of Vascular Remodeling Induced by Wall Shear Stress
por: Chen, Shiliang, et al.
Publicado: (2022)

Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms
por: Malashicheva, Anna, et al.
Publicado: (2016)

Inhibition of Aortic Intimal Hyperplasia and Vascular Smooth Muscle Proliferation and Extracellular Matrix Protein Expressions by Astragalus–Angelica Combination
por: Yan, Huifang, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_bk57uihgqdtijo63rvokce8dfg