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IDO Expression in Cancer: Different Compartment, Different Functionality?
Indoleamine 2,3-dioxygenase 1 (IDO1) is a cytosolic haem-containing enzyme involved in the degradation of tryptophan to kynurenine. Although initially thought to be solely implicated in the modulation of innate immune responses during infection, subsequent discoveries demonstrated IDO1 as a mechanis...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541907/ https://www.ncbi.nlm.nih.gov/pubmed/33072086 http://dx.doi.org/10.3389/fimmu.2020.531491 |
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author | Meireson, Annabel Devos, Michael Brochez, Lieve |
author_facet | Meireson, Annabel Devos, Michael Brochez, Lieve |
author_sort | Meireson, Annabel |
collection | PubMed |
description | Indoleamine 2,3-dioxygenase 1 (IDO1) is a cytosolic haem-containing enzyme involved in the degradation of tryptophan to kynurenine. Although initially thought to be solely implicated in the modulation of innate immune responses during infection, subsequent discoveries demonstrated IDO1 as a mechanism of acquired immune tolerance. In cancer, IDO1 expression/activity has been observed in tumor cells as well as in the tumor-surrounding stroma, which is composed of endothelial cells, immune cells, fibroblasts, and mesenchymal cells. IDO1 expression/activity has also been reported in the peripheral blood. This manuscript reviews available data on IDO1 expression, mechanisms of its induction, and its function in cancer for each of these compartments. In-depth study of the biological function of IDO1 according to the expressing (tumor) cell can help to understand if and when IDO1 inhibition can play a role in cancer therapy. |
format | Online Article Text |
id | pubmed-7541907 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75419072020-10-17 IDO Expression in Cancer: Different Compartment, Different Functionality? Meireson, Annabel Devos, Michael Brochez, Lieve Front Immunol Immunology Indoleamine 2,3-dioxygenase 1 (IDO1) is a cytosolic haem-containing enzyme involved in the degradation of tryptophan to kynurenine. Although initially thought to be solely implicated in the modulation of innate immune responses during infection, subsequent discoveries demonstrated IDO1 as a mechanism of acquired immune tolerance. In cancer, IDO1 expression/activity has been observed in tumor cells as well as in the tumor-surrounding stroma, which is composed of endothelial cells, immune cells, fibroblasts, and mesenchymal cells. IDO1 expression/activity has also been reported in the peripheral blood. This manuscript reviews available data on IDO1 expression, mechanisms of its induction, and its function in cancer for each of these compartments. In-depth study of the biological function of IDO1 according to the expressing (tumor) cell can help to understand if and when IDO1 inhibition can play a role in cancer therapy. Frontiers Media S.A. 2020-09-24 /pmc/articles/PMC7541907/ /pubmed/33072086 http://dx.doi.org/10.3389/fimmu.2020.531491 Text en Copyright © 2020 Meireson, Devos and Brochez. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Meireson, Annabel Devos, Michael Brochez, Lieve IDO Expression in Cancer: Different Compartment, Different Functionality? |
title | IDO Expression in Cancer: Different Compartment, Different Functionality? |
title_full | IDO Expression in Cancer: Different Compartment, Different Functionality? |
title_fullStr | IDO Expression in Cancer: Different Compartment, Different Functionality? |
title_full_unstemmed | IDO Expression in Cancer: Different Compartment, Different Functionality? |
title_short | IDO Expression in Cancer: Different Compartment, Different Functionality? |
title_sort | ido expression in cancer: different compartment, different functionality? |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541907/ https://www.ncbi.nlm.nih.gov/pubmed/33072086 http://dx.doi.org/10.3389/fimmu.2020.531491 |
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