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A Potential Biomarker of Combination of Tumor Mutation Burden and Copy Number Alteration for Efficacy of Immunotherapy in KRAS-Mutant Advanced Lung Adenocarcinoma

OBJECTIVES: The Kirsten Rat Sarcoma (KRAS) mutation is the commonest oncogenic drive mutation in lung adenocarcinoma (LUAD) and immunotherapy may be quite promising for KRAS-mutant LUAD. While the effects of tumor mutation burden (TMB) and copy number alteration (CNA) are poorly understood in this i...

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Detalles Bibliográficos
Autores principales:	Xiang, Luochengling, Fu, Xiao, Wang, Xiao, Li, Wenyuan, Zheng, Xiaoqiang, Nan, Kejun, Tian, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541961/ https://www.ncbi.nlm.nih.gov/pubmed/33072585 http://dx.doi.org/10.3389/fonc.2020.559896

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