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Clinical Features and Outcomes of Intracranial Aneurysm Associated with Moyamoya Disease
BACKGROUND AND PURPOSE: Moyamoya disease (MMD) is a rare form of intracranial stenoocclusive disease that can be associated with intracranial aneurysms. We evaluated the clinical features and outcomes of MMD-associated aneurysms while focusing on their locations. METHODS: Between January 1998 and De...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Neurological Association
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541995/ https://www.ncbi.nlm.nih.gov/pubmed/33029969 http://dx.doi.org/10.3988/jcn.2020.16.4.624 |
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author | Kim, Sunghan Jang, Chang Ki Park, Eun-Kyung Shim, Kyu-Won Kim, Dong-Seok Chung, Joonho Kim, Yong Bae Lee, Jae Whan Park, Keun Young |
author_facet | Kim, Sunghan Jang, Chang Ki Park, Eun-Kyung Shim, Kyu-Won Kim, Dong-Seok Chung, Joonho Kim, Yong Bae Lee, Jae Whan Park, Keun Young |
author_sort | Kim, Sunghan |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Moyamoya disease (MMD) is a rare form of intracranial stenoocclusive disease that can be associated with intracranial aneurysms. We evaluated the clinical features and outcomes of MMD-associated aneurysms while focusing on their locations. METHODS: Between January 1998 and December 2018 there were 1,302 adult and pediatric patients diagnosed as MMD at a single institution. These patients included 38 with 44 MMD-associated aneurysms. The MMD-associated aneurysms were classified into two groups based on their locations: major-artery aneurysms and non-major-artery aneurysms. The clinical and radiological data for patients with MMD-associated aneurysms were reviewed retrospectively. RESULTS: The 44 MMD-associated aneurysms comprised 28 in major arteries and 16 in nonmajor arteries. All of the major-artery aneurysms were initially unruptured lesions, and follow-up angiography showed that 23 (82.1%) had an improved or stable status and 5 (17.9%) had a worse status. The non-major-artery aneurysms comprised 10 ruptured and 6 unruptured lesions, and follow-up angiography showed that 11 (68.8%) had improved or were stable and 5 (31.2%) had worsened. At the latest follow-up, there were four cases of unfavorable outcome: two initial hemorrhagic insults, one treatment-related morbidity, and one repeated-hemorrhage case. CONCLUSIONS: MMD-associated aneurysms occurred in 3.3% of the MMD cohort in this study, of which 63.6% were major-artery aneurysms and 36.4% were non-major-artery aneurysms. The major-artery group included 17.9% that became angiographically worse, while 31.2% were growing or hemorrhaging in the non-major-artery group. |
format | Online Article Text |
id | pubmed-7541995 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Korean Neurological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-75419952020-10-19 Clinical Features and Outcomes of Intracranial Aneurysm Associated with Moyamoya Disease Kim, Sunghan Jang, Chang Ki Park, Eun-Kyung Shim, Kyu-Won Kim, Dong-Seok Chung, Joonho Kim, Yong Bae Lee, Jae Whan Park, Keun Young J Clin Neurol Original Article BACKGROUND AND PURPOSE: Moyamoya disease (MMD) is a rare form of intracranial stenoocclusive disease that can be associated with intracranial aneurysms. We evaluated the clinical features and outcomes of MMD-associated aneurysms while focusing on their locations. METHODS: Between January 1998 and December 2018 there were 1,302 adult and pediatric patients diagnosed as MMD at a single institution. These patients included 38 with 44 MMD-associated aneurysms. The MMD-associated aneurysms were classified into two groups based on their locations: major-artery aneurysms and non-major-artery aneurysms. The clinical and radiological data for patients with MMD-associated aneurysms were reviewed retrospectively. RESULTS: The 44 MMD-associated aneurysms comprised 28 in major arteries and 16 in nonmajor arteries. All of the major-artery aneurysms were initially unruptured lesions, and follow-up angiography showed that 23 (82.1%) had an improved or stable status and 5 (17.9%) had a worse status. The non-major-artery aneurysms comprised 10 ruptured and 6 unruptured lesions, and follow-up angiography showed that 11 (68.8%) had improved or were stable and 5 (31.2%) had worsened. At the latest follow-up, there were four cases of unfavorable outcome: two initial hemorrhagic insults, one treatment-related morbidity, and one repeated-hemorrhage case. CONCLUSIONS: MMD-associated aneurysms occurred in 3.3% of the MMD cohort in this study, of which 63.6% were major-artery aneurysms and 36.4% were non-major-artery aneurysms. The major-artery group included 17.9% that became angiographically worse, while 31.2% were growing or hemorrhaging in the non-major-artery group. Korean Neurological Association 2020-10 2020-09-25 /pmc/articles/PMC7541995/ /pubmed/33029969 http://dx.doi.org/10.3988/jcn.2020.16.4.624 Text en Copyright © 2020 Korean Neurological Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Sunghan Jang, Chang Ki Park, Eun-Kyung Shim, Kyu-Won Kim, Dong-Seok Chung, Joonho Kim, Yong Bae Lee, Jae Whan Park, Keun Young Clinical Features and Outcomes of Intracranial Aneurysm Associated with Moyamoya Disease |
title | Clinical Features and Outcomes of Intracranial Aneurysm Associated with Moyamoya Disease |
title_full | Clinical Features and Outcomes of Intracranial Aneurysm Associated with Moyamoya Disease |
title_fullStr | Clinical Features and Outcomes of Intracranial Aneurysm Associated with Moyamoya Disease |
title_full_unstemmed | Clinical Features and Outcomes of Intracranial Aneurysm Associated with Moyamoya Disease |
title_short | Clinical Features and Outcomes of Intracranial Aneurysm Associated with Moyamoya Disease |
title_sort | clinical features and outcomes of intracranial aneurysm associated with moyamoya disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541995/ https://www.ncbi.nlm.nih.gov/pubmed/33029969 http://dx.doi.org/10.3988/jcn.2020.16.4.624 |
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