Increased canonical NF-kappaB signaling specifically in macrophages is sufficient to limit tumor progression in syngeneic murine models of ovarian cancer

BACKGROUND: New treatment options for ovarian cancer are urgently required. Tumor-associated macrophages (TAMs) are an attractive target for therapy; repolarizing TAMs from M2 (pro-tumor) to M1 (anti-tumor) phenotypes represents an important therapeutic goal. We have previously shown that upregulate...

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Detalles Bibliográficos
Autores principales: Hoover, Alyssa A., Hufnagel, Demetra H., Harris, Whitney, Bullock, Kennady, Glass, Evan B., Liu, Esther, Barham, Whitney, Crispens, Marta A., Khabele, Dineo, Giorgio, Todd D., Wilson, Andrew J., Yull, Fiona E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542116/
https://www.ncbi.nlm.nih.gov/pubmed/33028251
http://dx.doi.org/10.1186/s12885-020-07450-8

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