Cargando…

Novel Small-Molecule Inhibitor for the Oncogenic Tyrosine Phosphatase SHP2 with Anti-Breast Cancer Cell Effects

[Image: see text] The oncogenic property of the Src homology phosphotyrosine phosphatase 2 (SHP2) is well-known, but developing specific inhibitors has been very difficult. Based on our previous reports that showed the importance of acidic residues surrounding SHP2 substrate phosphotyrosines for spe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hartman, Zachary, Geldenhuys, Werner J., Agazie, Yehenew M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542598/ https://www.ncbi.nlm.nih.gov/pubmed/33043190 http://dx.doi.org/10.1021/acsomega.0c02746

Ejemplares similares

SHP2 Potentiates the Oncogenic Activity of β-Catenin to Promote Triple-Negative Breast Cancer
por: Martin, Elisha, et al.
Publicado: (2021)

Targeting SHP2 with an Active Site Inhibitor Blocks Signaling and Breast Cancer Cell Phenotypes
por: Lade, Dhanaji M., et al.
Publicado: (2023)

SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal-like and triple-negative breast cancer
por: Matalkah, Fatimah, et al.
Publicado: (2016)

Inhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment
por: Zhao, Hua, et al.
Publicado: (2015)

Discovery of novel furanylbenzamide inhibitors that target oncogenic tyrosine phosphatase SHP2 in leukemia cells
por: Raveendra-Panickar, Dhanya, et al.
Publicado: (2021)

Discovery of a Novel Inhibitor of the Protein Tyrosine Phosphatase Shp2
por: Chen, Chuan, et al.
Publicado: (2015)

Conditional knockout of SHP2 in ErbB2 transgenic mice or inhibition in HER2-amplified breast cancer cell lines blocks oncogene expression and tumorigenesis
por: Zhao, Hua, et al.
Publicado: (2018)

The Allosteric Site on SHP2’s Protein Tyrosine Phosphatase Domain is Targetable with Druglike Small Molecules
por: Marsh-Armstrong, Brennan, et al.
Publicado: (2018)

Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies
por: Song, Zhendong, et al.
Publicado: (2021)

HER2 Stabilizes EGFR and Itself by Altering Autophosphorylation Patterns in a Manner That Overcomes Regulatory Mechanisms and Promotes Proliferative and Transformation Signaling
por: Hartman, Zachary, et al.
Publicado: (2012)

Overexpression of SHP2 tyrosine phosphatase promotes the tumorigenesis of breast carcinoma
por: Hu, Zhongqian, et al.
Publicado: (2017)

Targeting a Cryptic Allosteric Site for Selective Inhibition of the Oncogenic Protein Tyrosine Phosphatase Shp2
por: Chio, Cynthia M., et al.
Publicado: (2014)

Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase
por: Zeng, Li-Fan, et al.
Publicado: (2014)

Regulation of autoimmune arthritis by the SHP-1 tyrosine phosphatase
por: Markovics, Adrienn, et al.
Publicado: (2020)

Inhibition of SHP2 and SHP1 Protein Tyrosine Phosphatase Activity by Chemically Induced Dimerization
por: Buck, Sara J. S., et al.
Publicado: (2022)

Determination of the molecular reach of the protein tyrosine phosphatase SHP-1
por: Clemens, Lara, et al.
Publicado: (2021)

The function of Shp2 tyrosine phosphatase in the dispersal of acetylcholine receptor clusters
por: Qian, Yueping K, et al.
Publicado: (2008)

Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis
por: Liu, Xia, et al.
Publicado: (2011)

Role of the Protein Tyrosine Phosphatase Shp2 in Homeostasis of the Intestinal Epithelium
por: Yamashita, Hironori, et al.
Publicado: (2014)

Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis
por: Heun, Yvonn, et al.
Publicado: (2019)

An allosteric interaction controls the activation mechanism of SHP2 tyrosine phosphatase
por: Anselmi, Massimiliano, et al.
Publicado: (2020)

The role of tyrosine phosphatase Shp2 in spermatogonial differentiation and spermatocyte meiosis
por: Li, Yang, et al.
Publicado: (2019)

The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance?
por: Saint-Laurent, Céline, et al.
Publicado: (2022)

A tyrosine phosphatase SHP2 gain-of-function mutation enhances malignancy of breast carcinoma
por: Hu, Zhongqian, et al.
Publicado: (2015)

Protein Tyrosine Phosphatase SHP2 Controls Interleukin-8 Expression in Breast Cancer Cells
por: Amante, Romain J., et al.
Publicado: (2022)

Destabilization of the SHP2 and SHP1 protein tyrosine phosphatase domains by a non-conserved “backdoor” cysteine
por: Yarnall, Matthew T.N., et al.
Publicado: (2022)

Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice
por: Hu, Xiaopeng, et al.
Publicado: (2015)

Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2
por: Xia, L-x, et al.
Publicado: (2016)

Protein Tyrosine Phosphatase Non-Receptor 11 (PTPN11/Shp2) as a Driver Oncogene and a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC)
por: Richards, Cathy E., et al.
Publicado: (2023)

Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuria
por: Hsu, Ming-Fo, et al.
Publicado: (2017)

Role of the Tyrosine Phosphatase SHP-2 in Mediating Adrenomedullin Proangiogenic Activity in Solid Tumors
por: Sigaud, Romain, et al.
Publicado: (2021)

Impact of SHP2 tyrosine phosphorylation on the development of acquired resistance to allosteric SHP2 inhibitors
por: Franciosa, Giulia, et al.
Publicado: (2023)

Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment
por: Pardella, Elisa, et al.
Publicado: (2020)

Tyrosine Phosphatase Shp2 Mediates the Estrogen Biological Action in Breast Cancer via Interaction with the Estrogen Extranuclear Receptor
por: Li, Jun, et al.
Publicado: (2014)

Protein tyrosine phosphatase SHP2 promotes invadopodia formation through suppression of Rho signaling
por: Tsai, Wan-Chen, et al.
Publicado: (2015)

Cx43 Promotes Endothelial Cell Migration and Angiogenesis via the Tyrosine Phosphatase SHP-2
por: Mannell, Hanna, et al.
Publicado: (2021)

Modeling (not so) rare developmental disorders associated with mutations in the protein-tyrosine phosphatase SHP2
por: Solman, Maja, et al.
Publicado: (2022)

Protein Tyrosine Phosphatases, TC-PTP, SHP1, and SHP2, Cooperate in Rapid Dephosphorylation of Stat3 in Keratinocytes Following UVB Irradiation
por: Kim, Dae Joon, et al.
Publicado: (2010)

Sepsis-Induced Cardiac Mitochondrial Dysfunction Involves Altered Mitochondrial-Localization of Tyrosine Kinase Src and Tyrosine Phosphatase SHP2
por: Zang, Qun S., et al.
Publicado: (2012)

Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase
por: Mattila, Elina, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ejp2ndss43hmgq7vb5bjjjdoon