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2,5-dimethylcelecoxib improves immune microenvironment of hepatocellular carcinoma by promoting ubiquitination of HBx-induced PD-L1

BACKGROUND: 2,5-dimethylcelecoxib (DMC) is a targeted inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), a key enzyme in the PGE2 synthesis pathway of inflammatory mediators. Previous studies have confirmed that DMC can inhibit the growth of hepatitis B virus (HBV)-related hepatocellular...

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Detalles Bibliográficos
Autores principales:	Chen, Zhanfei, Chen, Yiyin, Peng, Lirong, Wang, Xiaoqian, Tang, Nanhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542662/ https://www.ncbi.nlm.nih.gov/pubmed/33028694 http://dx.doi.org/10.1136/jitc-2020-001377

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