Endosomal dysfunction in iPSC-derived neural cells from Parkinson’s disease patients with VPS35 D620N

Mutations in the Vacuolar protein sorting 35 (VPS35) gene have been linked to familial Parkinson’s disease (PD), PARK17. VPS35 is a key component of the retromer complex, which plays a central role in endosomal trafficking. However, whether and how VPS35 deficiency or mutation contributes to PD path...

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Detalles Bibliográficos
Autores principales: Bono, Keiko, Hara-Miyauchi, Chikako, Sumi, Shunsuke, Oka, Hisayoshi, Iguchi, Yasuyuki, Okano, Hirotaka James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542911/
https://www.ncbi.nlm.nih.gov/pubmed/33032646
http://dx.doi.org/10.1186/s13041-020-00675-5

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