Cargando…
The potential of lactoferrin, ovotransferrin and lysozyme as antiviral and immune-modulating agents in COVID-19
Coronavirus disease 2019 (COVID-19), caused by SARS coronavirus 2 (SARS-CoV-2), is spreading rapidly with no established effective treatments. While most cases are mild, others experience uncontrolled inflammatory responses with oxidative stress, dysregulation of iron and coagulation as features. La...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Medicine Ltd
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543043/ http://dx.doi.org/10.2217/fvl-2020-0170 |
_version_ | 1783591659290755072 |
---|---|
author | Mann, Jaclyn Kelly Ndung'u, Thumbi |
author_facet | Mann, Jaclyn Kelly Ndung'u, Thumbi |
author_sort | Mann, Jaclyn Kelly |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19), caused by SARS coronavirus 2 (SARS-CoV-2), is spreading rapidly with no established effective treatments. While most cases are mild, others experience uncontrolled inflammatory responses with oxidative stress, dysregulation of iron and coagulation as features. Lactoferrin, ovotransferrin and lysozyme are abundant, safe antimicrobials that have wide antiviral as well as immunomodulatory properties. In particular, lactoferrin restores iron homeostasis and inhibits replication of SARS-CoV, which is closely related to SARS-CoV-2. Ovotransferrin has antiviral peptides and activities that are shared with lactoferrin. Both lactoferrin and lysozyme are ‘immune sensing’ as they may stimulate immune responses or resolve inflammation. Mechanisms by which these antimicrobials may treat or prevent COVID-19, as well as sources and forms of these, are reviewed. |
format | Online Article Text |
id | pubmed-7543043 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Future Medicine Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-75430432020-10-08 The potential of lactoferrin, ovotransferrin and lysozyme as antiviral and immune-modulating agents in COVID-19 Mann, Jaclyn Kelly Ndung'u, Thumbi Future Virol Review Coronavirus disease 2019 (COVID-19), caused by SARS coronavirus 2 (SARS-CoV-2), is spreading rapidly with no established effective treatments. While most cases are mild, others experience uncontrolled inflammatory responses with oxidative stress, dysregulation of iron and coagulation as features. Lactoferrin, ovotransferrin and lysozyme are abundant, safe antimicrobials that have wide antiviral as well as immunomodulatory properties. In particular, lactoferrin restores iron homeostasis and inhibits replication of SARS-CoV, which is closely related to SARS-CoV-2. Ovotransferrin has antiviral peptides and activities that are shared with lactoferrin. Both lactoferrin and lysozyme are ‘immune sensing’ as they may stimulate immune responses or resolve inflammation. Mechanisms by which these antimicrobials may treat or prevent COVID-19, as well as sources and forms of these, are reviewed. Future Medicine Ltd 2020-10-08 2020-09 /pmc/articles/PMC7543043/ http://dx.doi.org/10.2217/fvl-2020-0170 Text en © 2020 Future Medicine Ltd This work is licensed under the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Review Mann, Jaclyn Kelly Ndung'u, Thumbi The potential of lactoferrin, ovotransferrin and lysozyme as antiviral and immune-modulating agents in COVID-19 |
title | The potential of lactoferrin, ovotransferrin and lysozyme as antiviral and immune-modulating agents in COVID-19 |
title_full | The potential of lactoferrin, ovotransferrin and lysozyme as antiviral and immune-modulating agents in COVID-19 |
title_fullStr | The potential of lactoferrin, ovotransferrin and lysozyme as antiviral and immune-modulating agents in COVID-19 |
title_full_unstemmed | The potential of lactoferrin, ovotransferrin and lysozyme as antiviral and immune-modulating agents in COVID-19 |
title_short | The potential of lactoferrin, ovotransferrin and lysozyme as antiviral and immune-modulating agents in COVID-19 |
title_sort | potential of lactoferrin, ovotransferrin and lysozyme as antiviral and immune-modulating agents in covid-19 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543043/ http://dx.doi.org/10.2217/fvl-2020-0170 |
work_keys_str_mv | AT mannjaclynkelly thepotentialoflactoferrinovotransferrinandlysozymeasantiviralandimmunemodulatingagentsincovid19 AT ndunguthumbi thepotentialoflactoferrinovotransferrinandlysozymeasantiviralandimmunemodulatingagentsincovid19 AT mannjaclynkelly potentialoflactoferrinovotransferrinandlysozymeasantiviralandimmunemodulatingagentsincovid19 AT ndunguthumbi potentialoflactoferrinovotransferrinandlysozymeasantiviralandimmunemodulatingagentsincovid19 |