PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

Inhibitory signals through the PD-1 pathway regulate T cell activation, T cell tolerance, and T cell exhaustion. Studies of PD-1 function have focused primarily on effector T cells. Far less is known about PD-1 function in regulatory T (T reg) cells. To study the role of PD-1 in T reg cells, we gene...

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Detalles Bibliográficos
Autores principales: Tan, Catherine L., Kuchroo, Juhi R., Sage, Peter T., Liang, Dan, Francisco, Loise M., Buck, Jessica, Thaker, Youg Raj, Zhang, Qianxia, McArdel, Shannon L., Juneja, Vikram R., Lee, Sun Jung, Lovitch, Scott B., Lian, Christine, Murphy, George F., Blazar, Bruce R., Vignali, Dario A.A., Freeman, Gordon J., Sharpe, Arlene H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543091/
https://www.ncbi.nlm.nih.gov/pubmed/33045061
http://dx.doi.org/10.1084/jem.20182232

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