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Collapsing Focal Segmental Glomerulosclerosis and Acute Oxalate Nephropathy in a Patient With COVID-19: A Double Whammy
As COVID-19 (coronavirus disease 2019) spreads across the world multiple therapeutic interventions have been tried to reduce morbidity and mortality. We describe a case of collapsing focal sclerosing glomerulosclerosis (FSGS) and acute oxalate nephropathy in a patient treated with high-dose intraven...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543098/ https://www.ncbi.nlm.nih.gov/pubmed/33019829 http://dx.doi.org/10.1177/2324709620963635 |
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author | Malhotra, Varun Magoon, Sandeep Troyer, Dean A. McCune, Thomas R. |
author_facet | Malhotra, Varun Magoon, Sandeep Troyer, Dean A. McCune, Thomas R. |
author_sort | Malhotra, Varun |
collection | PubMed |
description | As COVID-19 (coronavirus disease 2019) spreads across the world multiple therapeutic interventions have been tried to reduce morbidity and mortality. We describe a case of collapsing focal sclerosing glomerulosclerosis (FSGS) and acute oxalate nephropathy in a patient treated with high-dose intravenous vitamin C for severe COVID-19 infection. Collapsing FSGS has been described in patients with COVID-19 infection associated with APOL-1; however, this case had collapsing FSGS developing in low-risk heterozygous APOL-1 variant, and we postulate that the intensity of the COVID-19 cytokine storm overwhelmed the protective state of APOL-1 heterozygosity. This case illustrates the importance of assessing the risk and benefit of planned therapeutic interventions on a case-by-case basis especially when there are still so many unknowns in the management of COVID-19 infection. Strong consideration should be given for performing a renal biopsy in patients who develop multifactorial acute kidney injury. |
format | Online Article Text |
id | pubmed-7543098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-75430982020-10-20 Collapsing Focal Segmental Glomerulosclerosis and Acute Oxalate Nephropathy in a Patient With COVID-19: A Double Whammy Malhotra, Varun Magoon, Sandeep Troyer, Dean A. McCune, Thomas R. J Investig Med High Impact Case Rep Case Report As COVID-19 (coronavirus disease 2019) spreads across the world multiple therapeutic interventions have been tried to reduce morbidity and mortality. We describe a case of collapsing focal sclerosing glomerulosclerosis (FSGS) and acute oxalate nephropathy in a patient treated with high-dose intravenous vitamin C for severe COVID-19 infection. Collapsing FSGS has been described in patients with COVID-19 infection associated with APOL-1; however, this case had collapsing FSGS developing in low-risk heterozygous APOL-1 variant, and we postulate that the intensity of the COVID-19 cytokine storm overwhelmed the protective state of APOL-1 heterozygosity. This case illustrates the importance of assessing the risk and benefit of planned therapeutic interventions on a case-by-case basis especially when there are still so many unknowns in the management of COVID-19 infection. Strong consideration should be given for performing a renal biopsy in patients who develop multifactorial acute kidney injury. SAGE Publications 2020-10-05 /pmc/articles/PMC7543098/ /pubmed/33019829 http://dx.doi.org/10.1177/2324709620963635 Text en © 2020 American Federation for Medical Research https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Malhotra, Varun Magoon, Sandeep Troyer, Dean A. McCune, Thomas R. Collapsing Focal Segmental Glomerulosclerosis and Acute Oxalate Nephropathy in a Patient With COVID-19: A Double Whammy |
title | Collapsing Focal Segmental Glomerulosclerosis and Acute Oxalate
Nephropathy in a Patient With COVID-19: A Double Whammy |
title_full | Collapsing Focal Segmental Glomerulosclerosis and Acute Oxalate
Nephropathy in a Patient With COVID-19: A Double Whammy |
title_fullStr | Collapsing Focal Segmental Glomerulosclerosis and Acute Oxalate
Nephropathy in a Patient With COVID-19: A Double Whammy |
title_full_unstemmed | Collapsing Focal Segmental Glomerulosclerosis and Acute Oxalate
Nephropathy in a Patient With COVID-19: A Double Whammy |
title_short | Collapsing Focal Segmental Glomerulosclerosis and Acute Oxalate
Nephropathy in a Patient With COVID-19: A Double Whammy |
title_sort | collapsing focal segmental glomerulosclerosis and acute oxalate
nephropathy in a patient with covid-19: a double whammy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543098/ https://www.ncbi.nlm.nih.gov/pubmed/33019829 http://dx.doi.org/10.1177/2324709620963635 |
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