The role of aspirin in the prevention of ovarian, endometrial and cervical cancers

Drug repurposing is the application of an existing licenced drug for a new indication and potentially provides a faster and cheaper approach to developing new anti-cancer agents. Gynaecological cancers contribute significantly to the global cancer burden, highlighting the need for low cost, widely a...

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Autores principales: Joharatnam-Hogan, Nalinie, Cafferty, Fay H, Macnair, Archie, Ring, Alistair, Langley, Ruth E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543116/
https://www.ncbi.nlm.nih.gov/pubmed/33019903
http://dx.doi.org/10.1177/1745506520961710
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author Joharatnam-Hogan, Nalinie
Cafferty, Fay H
Macnair, Archie
Ring, Alistair
Langley, Ruth E
author_facet Joharatnam-Hogan, Nalinie
Cafferty, Fay H
Macnair, Archie
Ring, Alistair
Langley, Ruth E
author_sort Joharatnam-Hogan, Nalinie
collection PubMed
description Drug repurposing is the application of an existing licenced drug for a new indication and potentially provides a faster and cheaper approach to developing new anti-cancer agents. Gynaecological cancers contribute significantly to the global cancer burden, highlighting the need for low cost, widely accessible therapies. A large body of evidence supports the role of aspirin as an anti-cancer agent, and a number of randomized trials are currently underway aiming to assess the potential benefit of aspirin in the treatment of cancer. This review summarizes the evidence underpinning aspirin use for the prevention of the development and recurrence of gynaecological cancers (ovarian, endometrial and cervical) and potential mechanisms of action.
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spelling pubmed-75431162020-10-20 The role of aspirin in the prevention of ovarian, endometrial and cervical cancers Joharatnam-Hogan, Nalinie Cafferty, Fay H Macnair, Archie Ring, Alistair Langley, Ruth E Womens Health (Lond) Review Drug repurposing is the application of an existing licenced drug for a new indication and potentially provides a faster and cheaper approach to developing new anti-cancer agents. Gynaecological cancers contribute significantly to the global cancer burden, highlighting the need for low cost, widely accessible therapies. A large body of evidence supports the role of aspirin as an anti-cancer agent, and a number of randomized trials are currently underway aiming to assess the potential benefit of aspirin in the treatment of cancer. This review summarizes the evidence underpinning aspirin use for the prevention of the development and recurrence of gynaecological cancers (ovarian, endometrial and cervical) and potential mechanisms of action. SAGE Publications 2020-10-05 /pmc/articles/PMC7543116/ /pubmed/33019903 http://dx.doi.org/10.1177/1745506520961710 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Joharatnam-Hogan, Nalinie
Cafferty, Fay H
Macnair, Archie
Ring, Alistair
Langley, Ruth E
The role of aspirin in the prevention of ovarian, endometrial and cervical cancers
title The role of aspirin in the prevention of ovarian, endometrial and cervical cancers
title_full The role of aspirin in the prevention of ovarian, endometrial and cervical cancers
title_fullStr The role of aspirin in the prevention of ovarian, endometrial and cervical cancers
title_full_unstemmed The role of aspirin in the prevention of ovarian, endometrial and cervical cancers
title_short The role of aspirin in the prevention of ovarian, endometrial and cervical cancers
title_sort role of aspirin in the prevention of ovarian, endometrial and cervical cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543116/
https://www.ncbi.nlm.nih.gov/pubmed/33019903
http://dx.doi.org/10.1177/1745506520961710
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