Statin-Induced Rhabdomyolysis Due to Pharmacokinetic Changes From Biliary Obstruction in a Patient With Metastatic Prostate Cancer

Statins work synergistically with androgen receptor blockers and androgen biosynthesis inhibitors, improving survival in patients with metastatic castration resistant prostate cancers (mCRPCs). Survival improvement is more pronounced for patients receiving androgen biosynthesis inhibitors compared w...

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Detalles Bibliográficos
Autores principales: Desikan, Sai Prasad, Sobash, Phillip, Fisher, Andrew, Desikan, Raman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543161/
https://www.ncbi.nlm.nih.gov/pubmed/32755252
http://dx.doi.org/10.1177/2324709620947275
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author Desikan, Sai Prasad
Sobash, Phillip
Fisher, Andrew
Desikan, Raman
author_facet Desikan, Sai Prasad
Sobash, Phillip
Fisher, Andrew
Desikan, Raman
author_sort Desikan, Sai Prasad
collection PubMed
description Statins work synergistically with androgen receptor blockers and androgen biosynthesis inhibitors, improving survival in patients with metastatic castration resistant prostate cancers (mCRPCs). Survival improvement is more pronounced for patients receiving androgen biosynthesis inhibitors compared with patients receiving androgen receptor blockers. A rare adverse interaction between simvastatin and abiraterone (Zytiga), an androgen biosynthesis inhibitor, was observed in a patient with mCRPC due to pharmacokinetic changes resulting from obstructive jaundice.
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spelling pubmed-75431612020-10-20 Statin-Induced Rhabdomyolysis Due to Pharmacokinetic Changes From Biliary Obstruction in a Patient With Metastatic Prostate Cancer Desikan, Sai Prasad Sobash, Phillip Fisher, Andrew Desikan, Raman J Investig Med High Impact Case Rep Case Report Statins work synergistically with androgen receptor blockers and androgen biosynthesis inhibitors, improving survival in patients with metastatic castration resistant prostate cancers (mCRPCs). Survival improvement is more pronounced for patients receiving androgen biosynthesis inhibitors compared with patients receiving androgen receptor blockers. A rare adverse interaction between simvastatin and abiraterone (Zytiga), an androgen biosynthesis inhibitor, was observed in a patient with mCRPC due to pharmacokinetic changes resulting from obstructive jaundice. SAGE Publications 2020-08-05 /pmc/articles/PMC7543161/ /pubmed/32755252 http://dx.doi.org/10.1177/2324709620947275 Text en © 2020 American Federation for Medical Research https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Desikan, Sai Prasad
Sobash, Phillip
Fisher, Andrew
Desikan, Raman
Statin-Induced Rhabdomyolysis Due to Pharmacokinetic Changes From Biliary Obstruction in a Patient With Metastatic Prostate Cancer
title Statin-Induced Rhabdomyolysis Due to Pharmacokinetic Changes From Biliary Obstruction in a Patient With Metastatic Prostate Cancer
title_full Statin-Induced Rhabdomyolysis Due to Pharmacokinetic Changes From Biliary Obstruction in a Patient With Metastatic Prostate Cancer
title_fullStr Statin-Induced Rhabdomyolysis Due to Pharmacokinetic Changes From Biliary Obstruction in a Patient With Metastatic Prostate Cancer
title_full_unstemmed Statin-Induced Rhabdomyolysis Due to Pharmacokinetic Changes From Biliary Obstruction in a Patient With Metastatic Prostate Cancer
title_short Statin-Induced Rhabdomyolysis Due to Pharmacokinetic Changes From Biliary Obstruction in a Patient With Metastatic Prostate Cancer
title_sort statin-induced rhabdomyolysis due to pharmacokinetic changes from biliary obstruction in a patient with metastatic prostate cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543161/
https://www.ncbi.nlm.nih.gov/pubmed/32755252
http://dx.doi.org/10.1177/2324709620947275
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