Defibrotide for the Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 2 Pediatric Patients

The pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis/endotheliitis are suspected pathomechanisms, we treated 2 patients with...

Descripción completa

Detalles Bibliográficos
Autores principales: Lang, Peter, Eichholz, Thomas, Bakchoul, Tamam, Streiter, Monika, Petrasch, Maurice, Bösmüller, Hans, Klein, Reinhild, Rabsteyn, Armin, Lang, Anne-Marie, Adams, Constantin, Klingel, Karin, Gessner, Michaela, Rosenberger, Peter, Ruef, Peter, Handgretinger, Rupert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543556/
https://www.ncbi.nlm.nih.gov/pubmed/32951037
http://dx.doi.org/10.1093/jpids/piaa117
_version_ 1783591701971992576
author Lang, Peter
Eichholz, Thomas
Bakchoul, Tamam
Streiter, Monika
Petrasch, Maurice
Bösmüller, Hans
Klein, Reinhild
Rabsteyn, Armin
Lang, Anne-Marie
Adams, Constantin
Klingel, Karin
Gessner, Michaela
Rosenberger, Peter
Ruef, Peter
Handgretinger, Rupert
author_facet Lang, Peter
Eichholz, Thomas
Bakchoul, Tamam
Streiter, Monika
Petrasch, Maurice
Bösmüller, Hans
Klein, Reinhild
Rabsteyn, Armin
Lang, Anne-Marie
Adams, Constantin
Klingel, Karin
Gessner, Michaela
Rosenberger, Peter
Ruef, Peter
Handgretinger, Rupert
author_sort Lang, Peter
collection PubMed
description The pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis/endotheliitis are suspected pathomechanisms, we treated 2 patients with defibrotide, a profibrinolytic, antithrombotic, antiinflammatory oligonucleotide. Symptoms resolved during treatment. Moreover, coagulation parameters indicating hypofibrinolysis and complement activation normalized. The pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis/endotheliitis are suspected pathomechanisms, 2 patients received defibrotide, a profibrinolytic, antithrombotic, antiinflammatory oligonucleotide. Symptoms resolved and hypofibrinolysis/complement activation normalized during treatment.
format Online
Article
Text
id pubmed-7543556
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-75435562020-10-08 Defibrotide for the Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 2 Pediatric Patients Lang, Peter Eichholz, Thomas Bakchoul, Tamam Streiter, Monika Petrasch, Maurice Bösmüller, Hans Klein, Reinhild Rabsteyn, Armin Lang, Anne-Marie Adams, Constantin Klingel, Karin Gessner, Michaela Rosenberger, Peter Ruef, Peter Handgretinger, Rupert J Pediatric Infect Dis Soc Brief Reports The pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis/endotheliitis are suspected pathomechanisms, we treated 2 patients with defibrotide, a profibrinolytic, antithrombotic, antiinflammatory oligonucleotide. Symptoms resolved during treatment. Moreover, coagulation parameters indicating hypofibrinolysis and complement activation normalized. The pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis/endotheliitis are suspected pathomechanisms, 2 patients received defibrotide, a profibrinolytic, antithrombotic, antiinflammatory oligonucleotide. Symptoms resolved and hypofibrinolysis/complement activation normalized during treatment. Oxford University Press 2020-09-19 /pmc/articles/PMC7543556/ /pubmed/32951037 http://dx.doi.org/10.1093/jpids/piaa117 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Lang, Peter
Eichholz, Thomas
Bakchoul, Tamam
Streiter, Monika
Petrasch, Maurice
Bösmüller, Hans
Klein, Reinhild
Rabsteyn, Armin
Lang, Anne-Marie
Adams, Constantin
Klingel, Karin
Gessner, Michaela
Rosenberger, Peter
Ruef, Peter
Handgretinger, Rupert
Defibrotide for the Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 2 Pediatric Patients
title Defibrotide for the Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 2 Pediatric Patients
title_full Defibrotide for the Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 2 Pediatric Patients
title_fullStr Defibrotide for the Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 2 Pediatric Patients
title_full_unstemmed Defibrotide for the Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 2 Pediatric Patients
title_short Defibrotide for the Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 2 Pediatric Patients
title_sort defibrotide for the treatment of pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection in 2 pediatric patients
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543556/
https://www.ncbi.nlm.nih.gov/pubmed/32951037
http://dx.doi.org/10.1093/jpids/piaa117
work_keys_str_mv AT langpeter defibrotideforthetreatmentofpediatricinflammatorymultisystemsyndrometemporallyassociatedwithsevereacuterespiratorysyndromecoronavirus2infectionin2pediatricpatients
AT eichholzthomas defibrotideforthetreatmentofpediatricinflammatorymultisystemsyndrometemporallyassociatedwithsevereacuterespiratorysyndromecoronavirus2infectionin2pediatricpatients
AT bakchoultamam defibrotideforthetreatmentofpediatricinflammatorymultisystemsyndrometemporallyassociatedwithsevereacuterespiratorysyndromecoronavirus2infectionin2pediatricpatients
AT streitermonika defibrotideforthetreatmentofpediatricinflammatorymultisystemsyndrometemporallyassociatedwithsevereacuterespiratorysyndromecoronavirus2infectionin2pediatricpatients
AT petraschmaurice defibrotideforthetreatmentofpediatricinflammatorymultisystemsyndrometemporallyassociatedwithsevereacuterespiratorysyndromecoronavirus2infectionin2pediatricpatients
AT bosmullerhans defibrotideforthetreatmentofpediatricinflammatorymultisystemsyndrometemporallyassociatedwithsevereacuterespiratorysyndromecoronavirus2infectionin2pediatricpatients
AT kleinreinhild defibrotideforthetreatmentofpediatricinflammatorymultisystemsyndrometemporallyassociatedwithsevereacuterespiratorysyndromecoronavirus2infectionin2pediatricpatients
AT rabsteynarmin defibrotideforthetreatmentofpediatricinflammatorymultisystemsyndrometemporallyassociatedwithsevereacuterespiratorysyndromecoronavirus2infectionin2pediatricpatients
AT langannemarie defibrotideforthetreatmentofpediatricinflammatorymultisystemsyndrometemporallyassociatedwithsevereacuterespiratorysyndromecoronavirus2infectionin2pediatricpatients
AT adamsconstantin defibrotideforthetreatmentofpediatricinflammatorymultisystemsyndrometemporallyassociatedwithsevereacuterespiratorysyndromecoronavirus2infectionin2pediatricpatients
AT klingelkarin defibrotideforthetreatmentofpediatricinflammatorymultisystemsyndrometemporallyassociatedwithsevereacuterespiratorysyndromecoronavirus2infectionin2pediatricpatients
AT gessnermichaela defibrotideforthetreatmentofpediatricinflammatorymultisystemsyndrometemporallyassociatedwithsevereacuterespiratorysyndromecoronavirus2infectionin2pediatricpatients
AT rosenbergerpeter defibrotideforthetreatmentofpediatricinflammatorymultisystemsyndrometemporallyassociatedwithsevereacuterespiratorysyndromecoronavirus2infectionin2pediatricpatients
AT ruefpeter defibrotideforthetreatmentofpediatricinflammatorymultisystemsyndrometemporallyassociatedwithsevereacuterespiratorysyndromecoronavirus2infectionin2pediatricpatients
AT handgretingerrupert defibrotideforthetreatmentofpediatricinflammatorymultisystemsyndrometemporallyassociatedwithsevereacuterespiratorysyndromecoronavirus2infectionin2pediatricpatients

Ejemplares similares