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Maintaining Surgical Treatment of Non-Small Cell Lung Cancer During the COVID-19 Pandemic in Paris

BACKGROUND: The coronavirus disease 2019 (COVID-19) outbreak was officially declared in France on March 14, 2020. The objective of this study is to report the incidence and outcome of COVID-19 after surgical resection of non-small cell lung cancer in Paris Public Hospitals during the pandemic. METHO...

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Autores principales: Leclère, Jean-Baptiste, Fournel, Ludovic, Etienne, Harry, Al Zreibi, Charbel, Onorati, Ilaria, Roussel, Arnaud, Castier, Yves, Martinod, Emmanuel, Le Pimpec-Barthes, Françoise, Alifano, Marco, Assouad, Jalal, Mordant, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: by The Society of Thoracic Surgeons Published by Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543779/
https://www.ncbi.nlm.nih.gov/pubmed/33038341
http://dx.doi.org/10.1016/j.athoracsur.2020.08.007
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author Leclère, Jean-Baptiste
Fournel, Ludovic
Etienne, Harry
Al Zreibi, Charbel
Onorati, Ilaria
Roussel, Arnaud
Castier, Yves
Martinod, Emmanuel
Le Pimpec-Barthes, Françoise
Alifano, Marco
Assouad, Jalal
Mordant, Pierre
author_facet Leclère, Jean-Baptiste
Fournel, Ludovic
Etienne, Harry
Al Zreibi, Charbel
Onorati, Ilaria
Roussel, Arnaud
Castier, Yves
Martinod, Emmanuel
Le Pimpec-Barthes, Françoise
Alifano, Marco
Assouad, Jalal
Mordant, Pierre
author_sort Leclère, Jean-Baptiste
collection PubMed
description BACKGROUND: The coronavirus disease 2019 (COVID-19) outbreak was officially declared in France on March 14, 2020. The objective of this study is to report the incidence and outcome of COVID-19 after surgical resection of non-small cell lung cancer in Paris Public Hospitals during the pandemic. METHODS: We retrospective analyzed a prospective database including all patients who underwent non-small cell lung cancer resection between March 14, 2020, and May 11, 2020, in the 5 thoracic surgery units of Paris Public Hospitals. The primary endpoint was the occurrence of SARS-CoV-2 infection during the first 30 days after surgery. RESULTS: Study group included 115 patients (male 57%, age 64.6 ± 10.7 years, adenocarcinoma 66%, cT1 62%, cN0 82%). During the first month after surgery, 6 patients (5%) were diagnosed with COVID-19. As compared with COVID-negative patients, COVID-positive patients were more likely to be operated on during the first month of the pandemic (100% vs 54%, P = .03) and to be on corticosteroids preoperatively (33% vs 4%, P = .03). Postoperative COVID-19 was associated with an increased rate of readmission (50% vs 5%, P = .004), but no difference in 30-day morbidity (for the study group: grade 2, 24%; grade 3, 7%; grade 4, 1%) or mortality (n = 1 COVID-negative patient, 0.9%). Immediate oncologic outcomes did not differ significantly between groups (R0 resection 99%, nodal upstaging 14%, adjuvant chemotherapy 29%). CONCLUSIONS: During the COVID-19 pandemic, surgical treatment of non-small cell lung cancer was associated with a rate of postoperative COVID-19 of 5% with a significant impact on readmissions but not on other outcomes studied.
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spelling pubmed-75437792020-10-09 Maintaining Surgical Treatment of Non-Small Cell Lung Cancer During the COVID-19 Pandemic in Paris Leclère, Jean-Baptiste Fournel, Ludovic Etienne, Harry Al Zreibi, Charbel Onorati, Ilaria Roussel, Arnaud Castier, Yves Martinod, Emmanuel Le Pimpec-Barthes, Françoise Alifano, Marco Assouad, Jalal Mordant, Pierre Ann Thorac Surg Original Article BACKGROUND: The coronavirus disease 2019 (COVID-19) outbreak was officially declared in France on March 14, 2020. The objective of this study is to report the incidence and outcome of COVID-19 after surgical resection of non-small cell lung cancer in Paris Public Hospitals during the pandemic. METHODS: We retrospective analyzed a prospective database including all patients who underwent non-small cell lung cancer resection between March 14, 2020, and May 11, 2020, in the 5 thoracic surgery units of Paris Public Hospitals. The primary endpoint was the occurrence of SARS-CoV-2 infection during the first 30 days after surgery. RESULTS: Study group included 115 patients (male 57%, age 64.6 ± 10.7 years, adenocarcinoma 66%, cT1 62%, cN0 82%). During the first month after surgery, 6 patients (5%) were diagnosed with COVID-19. As compared with COVID-negative patients, COVID-positive patients were more likely to be operated on during the first month of the pandemic (100% vs 54%, P = .03) and to be on corticosteroids preoperatively (33% vs 4%, P = .03). Postoperative COVID-19 was associated with an increased rate of readmission (50% vs 5%, P = .004), but no difference in 30-day morbidity (for the study group: grade 2, 24%; grade 3, 7%; grade 4, 1%) or mortality (n = 1 COVID-negative patient, 0.9%). Immediate oncologic outcomes did not differ significantly between groups (R0 resection 99%, nodal upstaging 14%, adjuvant chemotherapy 29%). CONCLUSIONS: During the COVID-19 pandemic, surgical treatment of non-small cell lung cancer was associated with a rate of postoperative COVID-19 of 5% with a significant impact on readmissions but not on other outcomes studied. by The Society of Thoracic Surgeons Published by Elsevier 2021-05 2020-10-08 /pmc/articles/PMC7543779/ /pubmed/33038341 http://dx.doi.org/10.1016/j.athoracsur.2020.08.007 Text en © 2021 by The Society of Thoracic Surgeons Published by Elsevier. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Leclère, Jean-Baptiste
Fournel, Ludovic
Etienne, Harry
Al Zreibi, Charbel
Onorati, Ilaria
Roussel, Arnaud
Castier, Yves
Martinod, Emmanuel
Le Pimpec-Barthes, Françoise
Alifano, Marco
Assouad, Jalal
Mordant, Pierre
Maintaining Surgical Treatment of Non-Small Cell Lung Cancer During the COVID-19 Pandemic in Paris
title Maintaining Surgical Treatment of Non-Small Cell Lung Cancer During the COVID-19 Pandemic in Paris
title_full Maintaining Surgical Treatment of Non-Small Cell Lung Cancer During the COVID-19 Pandemic in Paris
title_fullStr Maintaining Surgical Treatment of Non-Small Cell Lung Cancer During the COVID-19 Pandemic in Paris
title_full_unstemmed Maintaining Surgical Treatment of Non-Small Cell Lung Cancer During the COVID-19 Pandemic in Paris
title_short Maintaining Surgical Treatment of Non-Small Cell Lung Cancer During the COVID-19 Pandemic in Paris
title_sort maintaining surgical treatment of non-small cell lung cancer during the covid-19 pandemic in paris
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543779/
https://www.ncbi.nlm.nih.gov/pubmed/33038341
http://dx.doi.org/10.1016/j.athoracsur.2020.08.007
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