Case Report: Adrenal Pathology Findings in Severe COVID-19: An Autopsy Study

Although high mortality has been reported in many COVID-19 studies, very limited postmortem information from complete autopsies is available. We report the findings in the adrenal glands in 28 autopsies with confirmed SARS-CoV-2 infection. Microscopic lesions were identified in the adrenal glands in...

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Detalles Bibliográficos
Autores principales: Freire Santana, Monique, Borba, Mayla Gabriela Silva, Baía-da-Silva, Djane Clarys, Val, Fernando, Alexandre, Márcia Almeida Araújo, Brito-Sousa, Jose Diego, Melo, Gisely Cardoso, Queiroga, Marcos Vinícius Oliveira, Leão Farias, Maria Eduarda, Camilo, Cecília Cunha, Naveca, Felipe Gomes, Xavier, Mariana Simão, Monteiro, Wuelton Marcelo, Augusto Pivoto João, Guilherme, Hajjar, Ludhmila Abrahão, Ordi, Jaume, Lacerda, Marcus Vinícius Guimarães, Ferreira, Luiz Carlos Lima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543860/
https://www.ncbi.nlm.nih.gov/pubmed/32876012
http://dx.doi.org/10.4269/ajtmh.20-0787
Descripción
Sumario:Although high mortality has been reported in many COVID-19 studies, very limited postmortem information from complete autopsies is available. We report the findings in the adrenal glands in 28 autopsies with confirmed SARS-CoV-2 infection. Microscopic lesions were identified in the adrenal glands in 12/28 patients (46%). Seven cases showed necrosis, generally ischemic; four showed cortical lipid degeneration; two showed hemorrhage; and one unspecific focal adrenalitis. Vascular thrombosis in one patient and focal inflammation in association with other findings in three patients were observed. No case presented adrenal insufficiency. In conclusion, adrenal lesions are frequent in patients with severe COVID-19. The lesions are mild but could contribute to the lethal outcome.

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