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Case Report: Adrenal Pathology Findings in Severe COVID-19: An Autopsy Study

Although high mortality has been reported in many COVID-19 studies, very limited postmortem information from complete autopsies is available. We report the findings in the adrenal glands in 28 autopsies with confirmed SARS-CoV-2 infection. Microscopic lesions were identified in the adrenal glands in...

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Autores principales: Freire Santana, Monique, Borba, Mayla Gabriela Silva, Baía-da-Silva, Djane Clarys, Val, Fernando, Alexandre, Márcia Almeida Araújo, Brito-Sousa, Jose Diego, Melo, Gisely Cardoso, Queiroga, Marcos Vinícius Oliveira, Leão Farias, Maria Eduarda, Camilo, Cecília Cunha, Naveca, Felipe Gomes, Xavier, Mariana Simão, Monteiro, Wuelton Marcelo, Augusto Pivoto João, Guilherme, Hajjar, Ludhmila Abrahão, Ordi, Jaume, Lacerda, Marcus Vinícius Guimarães, Ferreira, Luiz Carlos Lima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543860/
https://www.ncbi.nlm.nih.gov/pubmed/32876012
http://dx.doi.org/10.4269/ajtmh.20-0787
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author Freire Santana, Monique
Borba, Mayla Gabriela Silva
Baía-da-Silva, Djane Clarys
Val, Fernando
Alexandre, Márcia Almeida Araújo
Brito-Sousa, Jose Diego
Melo, Gisely Cardoso
Queiroga, Marcos Vinícius Oliveira
Leão Farias, Maria Eduarda
Camilo, Cecília Cunha
Naveca, Felipe Gomes
Xavier, Mariana Simão
Monteiro, Wuelton Marcelo
Augusto Pivoto João, Guilherme
Hajjar, Ludhmila Abrahão
Ordi, Jaume
Lacerda, Marcus Vinícius Guimarães
Ferreira, Luiz Carlos Lima
author_facet Freire Santana, Monique
Borba, Mayla Gabriela Silva
Baía-da-Silva, Djane Clarys
Val, Fernando
Alexandre, Márcia Almeida Araújo
Brito-Sousa, Jose Diego
Melo, Gisely Cardoso
Queiroga, Marcos Vinícius Oliveira
Leão Farias, Maria Eduarda
Camilo, Cecília Cunha
Naveca, Felipe Gomes
Xavier, Mariana Simão
Monteiro, Wuelton Marcelo
Augusto Pivoto João, Guilherme
Hajjar, Ludhmila Abrahão
Ordi, Jaume
Lacerda, Marcus Vinícius Guimarães
Ferreira, Luiz Carlos Lima
author_sort Freire Santana, Monique
collection PubMed
description Although high mortality has been reported in many COVID-19 studies, very limited postmortem information from complete autopsies is available. We report the findings in the adrenal glands in 28 autopsies with confirmed SARS-CoV-2 infection. Microscopic lesions were identified in the adrenal glands in 12/28 patients (46%). Seven cases showed necrosis, generally ischemic; four showed cortical lipid degeneration; two showed hemorrhage; and one unspecific focal adrenalitis. Vascular thrombosis in one patient and focal inflammation in association with other findings in three patients were observed. No case presented adrenal insufficiency. In conclusion, adrenal lesions are frequent in patients with severe COVID-19. The lesions are mild but could contribute to the lethal outcome.
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spelling pubmed-75438602020-10-11 Case Report: Adrenal Pathology Findings in Severe COVID-19: An Autopsy Study Freire Santana, Monique Borba, Mayla Gabriela Silva Baía-da-Silva, Djane Clarys Val, Fernando Alexandre, Márcia Almeida Araújo Brito-Sousa, Jose Diego Melo, Gisely Cardoso Queiroga, Marcos Vinícius Oliveira Leão Farias, Maria Eduarda Camilo, Cecília Cunha Naveca, Felipe Gomes Xavier, Mariana Simão Monteiro, Wuelton Marcelo Augusto Pivoto João, Guilherme Hajjar, Ludhmila Abrahão Ordi, Jaume Lacerda, Marcus Vinícius Guimarães Ferreira, Luiz Carlos Lima Am J Trop Med Hyg Articles Although high mortality has been reported in many COVID-19 studies, very limited postmortem information from complete autopsies is available. We report the findings in the adrenal glands in 28 autopsies with confirmed SARS-CoV-2 infection. Microscopic lesions were identified in the adrenal glands in 12/28 patients (46%). Seven cases showed necrosis, generally ischemic; four showed cortical lipid degeneration; two showed hemorrhage; and one unspecific focal adrenalitis. Vascular thrombosis in one patient and focal inflammation in association with other findings in three patients were observed. No case presented adrenal insufficiency. In conclusion, adrenal lesions are frequent in patients with severe COVID-19. The lesions are mild but could contribute to the lethal outcome. The American Society of Tropical Medicine and Hygiene 2020-10 2020-08-31 /pmc/articles/PMC7543860/ /pubmed/32876012 http://dx.doi.org/10.4269/ajtmh.20-0787 Text en © The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Articles
Freire Santana, Monique
Borba, Mayla Gabriela Silva
Baía-da-Silva, Djane Clarys
Val, Fernando
Alexandre, Márcia Almeida Araújo
Brito-Sousa, Jose Diego
Melo, Gisely Cardoso
Queiroga, Marcos Vinícius Oliveira
Leão Farias, Maria Eduarda
Camilo, Cecília Cunha
Naveca, Felipe Gomes
Xavier, Mariana Simão
Monteiro, Wuelton Marcelo
Augusto Pivoto João, Guilherme
Hajjar, Ludhmila Abrahão
Ordi, Jaume
Lacerda, Marcus Vinícius Guimarães
Ferreira, Luiz Carlos Lima
Case Report: Adrenal Pathology Findings in Severe COVID-19: An Autopsy Study
title Case Report: Adrenal Pathology Findings in Severe COVID-19: An Autopsy Study
title_full Case Report: Adrenal Pathology Findings in Severe COVID-19: An Autopsy Study
title_fullStr Case Report: Adrenal Pathology Findings in Severe COVID-19: An Autopsy Study
title_full_unstemmed Case Report: Adrenal Pathology Findings in Severe COVID-19: An Autopsy Study
title_short Case Report: Adrenal Pathology Findings in Severe COVID-19: An Autopsy Study
title_sort case report: adrenal pathology findings in severe covid-19: an autopsy study
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543860/
https://www.ncbi.nlm.nih.gov/pubmed/32876012
http://dx.doi.org/10.4269/ajtmh.20-0787
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