Challenges and future directions of potential natural products leads against 2019-nCoV outbreak

Except for Remdesivir® no other drug or vaccine has yet been approved to treat the coronavirus disease (COVID-19) caused by the virus known as, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Remdesivir® an small molecule and nucleic acid analogue, it is used to treat adults and childr...

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Autores principales: Ospanov, Meirambek, León, Francisco, Jenis, Janar, Khan, IKhlas A., Ibrahim, Mohamed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543902/
https://www.ncbi.nlm.nih.gov/pubmed/33052305
http://dx.doi.org/10.1016/j.cpb.2020.100180
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author Ospanov, Meirambek
León, Francisco
Jenis, Janar
Khan, IKhlas A.
Ibrahim, Mohamed A.
author_facet Ospanov, Meirambek
León, Francisco
Jenis, Janar
Khan, IKhlas A.
Ibrahim, Mohamed A.
author_sort Ospanov, Meirambek
collection PubMed
description Except for Remdesivir® no other drug or vaccine has yet been approved to treat the coronavirus disease (COVID-19) caused by the virus known as, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Remdesivir® an small molecule and nucleic acid analogue, it is used to treat adults and children with laboratory confirmed COVID-19, only administrated in hospital settings. Small molecules and particularly natural products count for almost fifty percent of the commercially available drugs, several of them are marketed antiviral agents and those can be a potential agent to treat COVID-19 infections. This short review rationalized different key natural products with known activity against coronaviruses as potential leads against COVID-19.
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spelling pubmed-75439022020-10-09 Challenges and future directions of potential natural products leads against 2019-nCoV outbreak Ospanov, Meirambek León, Francisco Jenis, Janar Khan, IKhlas A. Ibrahim, Mohamed A. Curr Plant Biol Review Article Except for Remdesivir® no other drug or vaccine has yet been approved to treat the coronavirus disease (COVID-19) caused by the virus known as, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Remdesivir® an small molecule and nucleic acid analogue, it is used to treat adults and children with laboratory confirmed COVID-19, only administrated in hospital settings. Small molecules and particularly natural products count for almost fifty percent of the commercially available drugs, several of them are marketed antiviral agents and those can be a potential agent to treat COVID-19 infections. This short review rationalized different key natural products with known activity against coronaviruses as potential leads against COVID-19. The Authors. Published by Elsevier B.V. 2020-12 2020-10-08 /pmc/articles/PMC7543902/ /pubmed/33052305 http://dx.doi.org/10.1016/j.cpb.2020.100180 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review Article
Ospanov, Meirambek
León, Francisco
Jenis, Janar
Khan, IKhlas A.
Ibrahim, Mohamed A.
Challenges and future directions of potential natural products leads against 2019-nCoV outbreak
title Challenges and future directions of potential natural products leads against 2019-nCoV outbreak
title_full Challenges and future directions of potential natural products leads against 2019-nCoV outbreak
title_fullStr Challenges and future directions of potential natural products leads against 2019-nCoV outbreak
title_full_unstemmed Challenges and future directions of potential natural products leads against 2019-nCoV outbreak
title_short Challenges and future directions of potential natural products leads against 2019-nCoV outbreak
title_sort challenges and future directions of potential natural products leads against 2019-ncov outbreak
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543902/
https://www.ncbi.nlm.nih.gov/pubmed/33052305
http://dx.doi.org/10.1016/j.cpb.2020.100180
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