Virus isolation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for diagnostic and research purposes

Isolation of the new pandemic virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for diagnostic and research purposes including assessment of novel therapeutics. Several primary and continuous cell lines are currently used, and new organoid and engineered cell lines are...

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Detalles Bibliográficos
Autores principales: Stelzer-Braid, Sacha, Walker, Gregory J., Aggarwal, Anupriya, Isaacs, Sonia R., Yeang, Malinna, Naing, Zin, Ospina Stella, Alberto, Turville, Stuart G., Rawlinson, William D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. on behalf of Royal College of Pathologists of Australasia. 2020
Materias:
FOCUS ON SARS-CoV-2
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543926/
https://www.ncbi.nlm.nih.gov/pubmed/33131800
http://dx.doi.org/10.1016/j.pathol.2020.09.012
Descripción
Sumario:Isolation of the new pandemic virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for diagnostic and research purposes including assessment of novel therapeutics. Several primary and continuous cell lines are currently used, and new organoid and engineered cell lines are being developed for improved investigation and understanding of the human immune response to this virus. Here we review the growth of SARS-CoV-2 in reference standard cell lines, engineered cell lines and new developments in this field.

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