Pro resolving inflammatory effects of the lipid mediators of omega 3 fatty acids and its implication in SARS COVID-19

COVID-19 is a new disease caused by coronavirus SARS-CoV-2. It was first described in 2019, developed into an epidemic in January 2020 and has spread the global to the present COVID-19 pandemic. Specialized pro‑resolving mediators (SPMs) may play a new role in the management of this lung disease bec...

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Autores principales: Regidor, Pedro-Antonio, Santos, Fernando Gonzalez, Rizo, Jose Miguel, Egea, Fernando Moreno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543931/
https://www.ncbi.nlm.nih.gov/pubmed/33069094
http://dx.doi.org/10.1016/j.mehy.2020.110340
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author Regidor, Pedro-Antonio
Santos, Fernando Gonzalez
Rizo, Jose Miguel
Egea, Fernando Moreno
author_facet Regidor, Pedro-Antonio
Santos, Fernando Gonzalez
Rizo, Jose Miguel
Egea, Fernando Moreno
author_sort Regidor, Pedro-Antonio
collection PubMed
description COVID-19 is a new disease caused by coronavirus SARS-CoV-2. It was first described in 2019, developed into an epidemic in January 2020 and has spread the global to the present COVID-19 pandemic. Specialized pro‑resolving mediators (SPMs) may play a new role in the management of this lung disease because SPM actively stimulate the resolution of infectious inflammation and are organ protective in animal disease models. Many tissues have been suitable targets for treating inflammation with SPMs or their active precursors 18-HEPE, 17-HDHA and the 14-HDHA, in order to elicit dynamic resolution of inflammation. Here we discuss the possible mode of action of these substances in the management of SARS Covid 19.
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spelling pubmed-75439312020-10-09 Pro resolving inflammatory effects of the lipid mediators of omega 3 fatty acids and its implication in SARS COVID-19 Regidor, Pedro-Antonio Santos, Fernando Gonzalez Rizo, Jose Miguel Egea, Fernando Moreno Med Hypotheses Article COVID-19 is a new disease caused by coronavirus SARS-CoV-2. It was first described in 2019, developed into an epidemic in January 2020 and has spread the global to the present COVID-19 pandemic. Specialized pro‑resolving mediators (SPMs) may play a new role in the management of this lung disease because SPM actively stimulate the resolution of infectious inflammation and are organ protective in animal disease models. Many tissues have been suitable targets for treating inflammation with SPMs or their active precursors 18-HEPE, 17-HDHA and the 14-HDHA, in order to elicit dynamic resolution of inflammation. Here we discuss the possible mode of action of these substances in the management of SARS Covid 19. The Authors. Published by Elsevier Ltd. 2020-12 2020-10-08 /pmc/articles/PMC7543931/ /pubmed/33069094 http://dx.doi.org/10.1016/j.mehy.2020.110340 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Regidor, Pedro-Antonio
Santos, Fernando Gonzalez
Rizo, Jose Miguel
Egea, Fernando Moreno
Pro resolving inflammatory effects of the lipid mediators of omega 3 fatty acids and its implication in SARS COVID-19
title Pro resolving inflammatory effects of the lipid mediators of omega 3 fatty acids and its implication in SARS COVID-19
title_full Pro resolving inflammatory effects of the lipid mediators of omega 3 fatty acids and its implication in SARS COVID-19
title_fullStr Pro resolving inflammatory effects of the lipid mediators of omega 3 fatty acids and its implication in SARS COVID-19
title_full_unstemmed Pro resolving inflammatory effects of the lipid mediators of omega 3 fatty acids and its implication in SARS COVID-19
title_short Pro resolving inflammatory effects of the lipid mediators of omega 3 fatty acids and its implication in SARS COVID-19
title_sort pro resolving inflammatory effects of the lipid mediators of omega 3 fatty acids and its implication in sars covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543931/
https://www.ncbi.nlm.nih.gov/pubmed/33069094
http://dx.doi.org/10.1016/j.mehy.2020.110340
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