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Prevalence of hyposmia and hypogeusia in 390 COVID-19 hospitalized patients and outpatients: a cross-sectional study

Anecdotal evidence rapidly accumulated during March 2020 from sites around the world that sudden hyposmia and hypogeusia are significant symptoms associated with the SARS-CoV-2 pandemic. Our objective was to describe the prevalence of hyposmia and hypogeusia and compare it in hospitalized and non-ho...

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Autores principales: Nouchi, Agathe, Chastang, Julie, Miyara, Makoto, Lejeune, Julie, Soares, André, Ibanez, Gladys, Saadoun, David, Morélot-Panzini, Capucine, Similowski, Thomas, Amoura, Zahir, Boddaert, Jacques, Caumes, Eric, Bleibtreu, Alexandre, Lorenzo, Alain, Tubach, Florence, Pourcher, Valérie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543958/
https://www.ncbi.nlm.nih.gov/pubmed/33033955
http://dx.doi.org/10.1007/s10096-020-04056-7
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author Nouchi, Agathe
Chastang, Julie
Miyara, Makoto
Lejeune, Julie
Soares, André
Ibanez, Gladys
Saadoun, David
Morélot-Panzini, Capucine
Similowski, Thomas
Amoura, Zahir
Boddaert, Jacques
Caumes, Eric
Bleibtreu, Alexandre
Lorenzo, Alain
Tubach, Florence
Pourcher, Valérie
author_facet Nouchi, Agathe
Chastang, Julie
Miyara, Makoto
Lejeune, Julie
Soares, André
Ibanez, Gladys
Saadoun, David
Morélot-Panzini, Capucine
Similowski, Thomas
Amoura, Zahir
Boddaert, Jacques
Caumes, Eric
Bleibtreu, Alexandre
Lorenzo, Alain
Tubach, Florence
Pourcher, Valérie
author_sort Nouchi, Agathe
collection PubMed
description Anecdotal evidence rapidly accumulated during March 2020 from sites around the world that sudden hyposmia and hypogeusia are significant symptoms associated with the SARS-CoV-2 pandemic. Our objective was to describe the prevalence of hyposmia and hypogeusia and compare it in hospitalized and non-hospitalized COVID-19 patients to evaluate an association of these symptoms with disease severity. We performed a cross-sectional survey during 5 consecutive days in March 2020, within a tertiary referral center, associated outpatient clinic, and two primary care outpatient facilities in Paris. All SARS-CoV-2-positive patients hospitalized during the study period and able to be interviewed (n = 198), hospital outpatients seen during the previous month (n = 129), and all COVID-19-highly suspect patients in two primary health centers (n = 63) were included. Hospitalized patients were significantly more often male (64 vs 40%) and older (66 vs 43 years old in median) and had significantly more comorbidities than outpatients. Hyposmia and hypogeusia were reported by 33% of patients and occurred significantly less frequently in hospitalized patients (12% and 13%, respectively) than in the health centers’ outpatients (33% and 43%, respectively) and in the hospital outpatients (65% and 60%, respectively). Hyposmia and hypogeusia appeared more frequently after other COVID-19 symptoms. Patients with hyposmia and/or hypogeusia were significantly younger and had significantly less respiratory severity criteria than patients without these symptoms. Olfactory and gustatory dysfunction occurs frequently in COVID-19, especially in young, non-severe patients. These symptoms might be a useful tool for initial diagnostic work-up in patients with suspected COVID-19.
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spelling pubmed-75439582020-10-09 Prevalence of hyposmia and hypogeusia in 390 COVID-19 hospitalized patients and outpatients: a cross-sectional study Nouchi, Agathe Chastang, Julie Miyara, Makoto Lejeune, Julie Soares, André Ibanez, Gladys Saadoun, David Morélot-Panzini, Capucine Similowski, Thomas Amoura, Zahir Boddaert, Jacques Caumes, Eric Bleibtreu, Alexandre Lorenzo, Alain Tubach, Florence Pourcher, Valérie Eur J Clin Microbiol Infect Dis Original Article Anecdotal evidence rapidly accumulated during March 2020 from sites around the world that sudden hyposmia and hypogeusia are significant symptoms associated with the SARS-CoV-2 pandemic. Our objective was to describe the prevalence of hyposmia and hypogeusia and compare it in hospitalized and non-hospitalized COVID-19 patients to evaluate an association of these symptoms with disease severity. We performed a cross-sectional survey during 5 consecutive days in March 2020, within a tertiary referral center, associated outpatient clinic, and two primary care outpatient facilities in Paris. All SARS-CoV-2-positive patients hospitalized during the study period and able to be interviewed (n = 198), hospital outpatients seen during the previous month (n = 129), and all COVID-19-highly suspect patients in two primary health centers (n = 63) were included. Hospitalized patients were significantly more often male (64 vs 40%) and older (66 vs 43 years old in median) and had significantly more comorbidities than outpatients. Hyposmia and hypogeusia were reported by 33% of patients and occurred significantly less frequently in hospitalized patients (12% and 13%, respectively) than in the health centers’ outpatients (33% and 43%, respectively) and in the hospital outpatients (65% and 60%, respectively). Hyposmia and hypogeusia appeared more frequently after other COVID-19 symptoms. Patients with hyposmia and/or hypogeusia were significantly younger and had significantly less respiratory severity criteria than patients without these symptoms. Olfactory and gustatory dysfunction occurs frequently in COVID-19, especially in young, non-severe patients. These symptoms might be a useful tool for initial diagnostic work-up in patients with suspected COVID-19. Springer Berlin Heidelberg 2020-10-08 2021 /pmc/articles/PMC7543958/ /pubmed/33033955 http://dx.doi.org/10.1007/s10096-020-04056-7 Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Nouchi, Agathe
Chastang, Julie
Miyara, Makoto
Lejeune, Julie
Soares, André
Ibanez, Gladys
Saadoun, David
Morélot-Panzini, Capucine
Similowski, Thomas
Amoura, Zahir
Boddaert, Jacques
Caumes, Eric
Bleibtreu, Alexandre
Lorenzo, Alain
Tubach, Florence
Pourcher, Valérie
Prevalence of hyposmia and hypogeusia in 390 COVID-19 hospitalized patients and outpatients: a cross-sectional study
title Prevalence of hyposmia and hypogeusia in 390 COVID-19 hospitalized patients and outpatients: a cross-sectional study
title_full Prevalence of hyposmia and hypogeusia in 390 COVID-19 hospitalized patients and outpatients: a cross-sectional study
title_fullStr Prevalence of hyposmia and hypogeusia in 390 COVID-19 hospitalized patients and outpatients: a cross-sectional study
title_full_unstemmed Prevalence of hyposmia and hypogeusia in 390 COVID-19 hospitalized patients and outpatients: a cross-sectional study
title_short Prevalence of hyposmia and hypogeusia in 390 COVID-19 hospitalized patients and outpatients: a cross-sectional study
title_sort prevalence of hyposmia and hypogeusia in 390 covid-19 hospitalized patients and outpatients: a cross-sectional study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543958/
https://www.ncbi.nlm.nih.gov/pubmed/33033955
http://dx.doi.org/10.1007/s10096-020-04056-7
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