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Adaptive immunity selects against malaria infection blocking mutations

The mutation responsible for Duffy negativity, which impedes Plasmodium vivax infection, has reached high frequencies in certain human populations. Conversely, mutations capable of blocking the more lethal P. falciparum have not succeeded in malarious zones. Here we present an evolutionary-epidemiol...

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Detalles Bibliográficos
Autores principales: Penman, Bridget S., Gandon, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544067/
https://www.ncbi.nlm.nih.gov/pubmed/33031369
http://dx.doi.org/10.1371/journal.pcbi.1008181