SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity

SAMHD1 is a host restriction factor that functions to restrict both retroviruses and DNA viruses, based on its nuclear deoxynucleotide triphosphate (dNTP) hydrolase activity that limits availability of intracellular dNTP pools. In the present study, we demonstrate that SAMHD1 expression was increase...

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Detalles Bibliográficos
Autores principales: De Meo, Simone, Dell’Oste, Valentina, Molfetta, Rosa, Tassinari, Valentina, Lotti, Lavinia Vittoria, Vespa, Simone, Pignoloni, Benedetta, Covino, Daniela Angela, Fantuzzi, Laura, Bona, Roberta, Zingoni, Alessandra, Nardone, Ilaria, Biolatti, Matteo, Coscia, Alessandra, Paolini, Rossella, Benkirane, Monsef, Edfors, Fredrik, Sandalova, Tatyana, Achour, Adnane, Hiscott, John, Landolfo, Santo, Santoni, Angela, Cerboni, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544099/
https://www.ncbi.nlm.nih.gov/pubmed/32986788
http://dx.doi.org/10.1371/journal.ppat.1008855

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