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Rapid declines in systolic blood pressure are associated with an increase in pulse transit time
BACKGROUND: The correlation between pulse transit time and blood pressure has been proposed as a route to measure continuous non-invasive blood pressure. We investigated whether pulse transit time trends could model blood pressure trends during episodes of rapid declines in blood pressure. METHODS:...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544103/ https://www.ncbi.nlm.nih.gov/pubmed/33031455 http://dx.doi.org/10.1371/journal.pone.0240126 |
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author | Schaanning, Sebastian Grøvdal Skjaervold, Nils Kristian |
author_facet | Schaanning, Sebastian Grøvdal Skjaervold, Nils Kristian |
author_sort | Schaanning, Sebastian Grøvdal |
collection | PubMed |
description | BACKGROUND: The correlation between pulse transit time and blood pressure has been proposed as a route to measure continuous non-invasive blood pressure. We investigated whether pulse transit time trends could model blood pressure trends during episodes of rapid declines in blood pressure. METHODS: From the Medical Information Mart for Intensive Care waveform database we identified substantial blood pressure reductions. Pulse transit time was calculated from the R-peak of the electrocardiogram to the peak of the arterial pulse waveform. The time-series were processed with a moving average filter before comparison. Averaged, continuous heart rate was also analysed as a control. The intra-individual association between variables was assessed per subject using linear regression. RESULTS: In the 511 patients included we found a median correlation coefficient between blood pressure and pulse transit time of -0.93 (IQR -0.98 to -0.76) with regression slopes of -1.23 mmHg/ms (IQR -1.73 to -0.81). The median correlation coefficient between blood pressure and heart rate was 0.46 (IQR -0.16 to 0.83). In supplementary analysis, results did not differ substantially when widening inclusion criteria, but the results were not always consistent within subjects across episodes of hypotension. CONCLUSIONS: In a large cohort of critically ill patients experiencing episodes of rapid declines in systolic blood pressure, there was a moderate-strong intra-individual correlation between averaged systolic blood pressure and averaged pulse transit time. Our findings encourage further investigation into using the pulse transit time for non-invasive real-time detection of hypotension. |
format | Online Article Text |
id | pubmed-7544103 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-75441032020-10-19 Rapid declines in systolic blood pressure are associated with an increase in pulse transit time Schaanning, Sebastian Grøvdal Skjaervold, Nils Kristian PLoS One Research Article BACKGROUND: The correlation between pulse transit time and blood pressure has been proposed as a route to measure continuous non-invasive blood pressure. We investigated whether pulse transit time trends could model blood pressure trends during episodes of rapid declines in blood pressure. METHODS: From the Medical Information Mart for Intensive Care waveform database we identified substantial blood pressure reductions. Pulse transit time was calculated from the R-peak of the electrocardiogram to the peak of the arterial pulse waveform. The time-series were processed with a moving average filter before comparison. Averaged, continuous heart rate was also analysed as a control. The intra-individual association between variables was assessed per subject using linear regression. RESULTS: In the 511 patients included we found a median correlation coefficient between blood pressure and pulse transit time of -0.93 (IQR -0.98 to -0.76) with regression slopes of -1.23 mmHg/ms (IQR -1.73 to -0.81). The median correlation coefficient between blood pressure and heart rate was 0.46 (IQR -0.16 to 0.83). In supplementary analysis, results did not differ substantially when widening inclusion criteria, but the results were not always consistent within subjects across episodes of hypotension. CONCLUSIONS: In a large cohort of critically ill patients experiencing episodes of rapid declines in systolic blood pressure, there was a moderate-strong intra-individual correlation between averaged systolic blood pressure and averaged pulse transit time. Our findings encourage further investigation into using the pulse transit time for non-invasive real-time detection of hypotension. Public Library of Science 2020-10-08 /pmc/articles/PMC7544103/ /pubmed/33031455 http://dx.doi.org/10.1371/journal.pone.0240126 Text en © 2020 Schaanning, Skjaervold http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Schaanning, Sebastian Grøvdal Skjaervold, Nils Kristian Rapid declines in systolic blood pressure are associated with an increase in pulse transit time |
title | Rapid declines in systolic blood pressure are associated with an increase in pulse transit time |
title_full | Rapid declines in systolic blood pressure are associated with an increase in pulse transit time |
title_fullStr | Rapid declines in systolic blood pressure are associated with an increase in pulse transit time |
title_full_unstemmed | Rapid declines in systolic blood pressure are associated with an increase in pulse transit time |
title_short | Rapid declines in systolic blood pressure are associated with an increase in pulse transit time |
title_sort | rapid declines in systolic blood pressure are associated with an increase in pulse transit time |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544103/ https://www.ncbi.nlm.nih.gov/pubmed/33031455 http://dx.doi.org/10.1371/journal.pone.0240126 |
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