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Base pairing, structural and functional insights into N(4)-methylcytidine (m(4)C) and N(4),N(4)-dimethylcytidine (m(4)(2)C) modified RNA

The N(4)-methylation of cytidine (m(4)C and m(4)(2)C) in RNA plays important roles in both bacterial and eukaryotic cells. In this work, we synthesized a series of m(4)C and m(4)(2)C modified RNA oligonucleotides, conducted their base pairing and bioactivity studies, and solved three new crystal str...

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Detalles Bibliográficos
Autores principales:	Mao, Song, Sekula, Bartosz, Ruszkowski, Milosz, Ranganathan, Srivathsan V, Haruehanroengra, Phensinee, Wu, Ying, Shen, Fusheng, Sheng, Jia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544196/ https://www.ncbi.nlm.nih.gov/pubmed/32941619 http://dx.doi.org/10.1093/nar/gkaa737

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