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Hedgehog signaling enables repair of ribosomal DNA double-strand breaks

Ribosomal DNA (rDNA) consists of highly repeated sequences that are prone to incurring damage. Delays or failure of rDNA double-strand break (DSB) repair are deleterious, and can lead to rDNA transcriptional arrest, chromosomal translocations, genomic losses, and cell death. Here, we show that the z...

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Detalles Bibliográficos
Autores principales:	Lama-Sherpa, Tshering D, Lin, Victor T G, Metge, Brandon J, Weeks, Shannon E, Chen, Dongquan, Samant, Rajeev S, Shevde, Lalita A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544215/ https://www.ncbi.nlm.nih.gov/pubmed/32894284 http://dx.doi.org/10.1093/nar/gkaa733

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