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Elements at the 5′ end of Xist harbor SPEN-independent transcriptional antiterminator activity

The Xist lncRNA requires Repeat A, a conserved RNA element located in its 5′ end, to induce gene silencing during X-chromosome inactivation. Intriguingly, Repeat A is also required for production of Xist. While silencing by Repeat A requires the protein SPEN, how Repeat A promotes Xist production re...

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Detalles Bibliográficos
Autores principales:	Trotman, Jackson B, Lee, David M, Cherney, Rachel E, Kim, Susan O, Inoue, Kaoru, Schertzer, Megan D, Bischoff, Steven R, Cowley, Dale O, Calabrese, J Mauro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544216/ https://www.ncbi.nlm.nih.gov/pubmed/32986830 http://dx.doi.org/10.1093/nar/gkaa789

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