Periphilin self-association underpins epigenetic silencing by the HUSH complex

Transcription of integrated DNA from viruses or transposable elements is tightly regulated to prevent pathogenesis. The Human Silencing Hub (HUSH), composed of Periphilin, TASOR and MPP8, silences transcriptionally active viral and endogenous transgenes. HUSH recruits effectors that alter the epigen...

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Detalles Bibliográficos
Autores principales: Prigozhin, Daniil M, Douse, Christopher H, Farleigh, Laura E, Albecka, Anna, Tchasovnikarova, Iva A, Timms, Richard T, Oda, Shun-ichiro, Adolf, Frank, Freund, Stefan M V, Maslen, Sarah, Lehner, Paul J, Modis, Yorgo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544229/
https://www.ncbi.nlm.nih.gov/pubmed/32976585
http://dx.doi.org/10.1093/nar/gkaa785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544229/
https://www.ncbi.nlm.nih.gov/pubmed/32976585
http://dx.doi.org/10.1093/nar/gkaa785

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