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Hyperprolactinemia in clinical non-functional pituitary macroadenomas: A STROBE-compliant study
Hyperprolactinemia is a prevalent endocrine disorder presented in patients with non-functional pituitary adenomas (NFPAs). However, the mechanism involved in hyperprolactinemia in NFPA is not fully illustrated. The current study aims to investigate predictors for hyperprolactinemia in NFPA via analy...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544428/ https://www.ncbi.nlm.nih.gov/pubmed/33031334 http://dx.doi.org/10.1097/MD.0000000000022673 |
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author | Lyu, Liang Yin, Senlin Hu, Yu Chen, Cheng Jiang, Yong Yu, Yang Ma, Weichao Wang, Zeming Jiang, Shu Zhou, Peizhi |
author_facet | Lyu, Liang Yin, Senlin Hu, Yu Chen, Cheng Jiang, Yong Yu, Yang Ma, Weichao Wang, Zeming Jiang, Shu Zhou, Peizhi |
author_sort | Lyu, Liang |
collection | PubMed |
description | Hyperprolactinemia is a prevalent endocrine disorder presented in patients with non-functional pituitary adenomas (NFPAs). However, the mechanism involved in hyperprolactinemia in NFPA is not fully illustrated. The current study aims to investigate predictors for hyperprolactinemia in NFPA via analyzing relevant clinical features. Thus, in this study, a cohort of 214 cases with integrated medical records was retrospectively analyzed concerning clinical, pathological, and endocrinological studies before and after surgery. Hyperprolactinemia happened in 93 cases (43.5%). Women (adjust odds ratio [OR] = 3.093; P < .01), age of patients (adjust OR = 0.951; P < .01), and serum free tetraiodothyronine (FT4) level (adjust OR = 0.882; P = .02) were independent predictors for developing preoperative hyperprolactinemia. Tumor size and hypopituitarism had no impact on hyperprolactinemia. During a median follow-up of 43.5 (range, 22–80) months, 83.9% patients with preoperative hyperprolactinemia experienced prolactin (PRL) normalization. Preoperative PRL level (adjusted OR = 1.741, P = .03) was the exclusive predictor for PRL normalization after adjusting for tumor volume, preoperative serum FT4 concentration, and postoperative residual. The PRL normalization rate of patients with lower PRL level (<2.35-fold upper limit of normal range) was 95.2% and decreased to 65.5% for patients with higher PRL level. In conclusion, our results suggest existence of potentially alternative mechanisms underlying hyperprolactinemia in NFPAs, like the discrepancy of sex and age and the negative feedback of FT4. Preoperative PRL is a predictor for postoperative PRL normalization, which is of clinically relevant for postoperative management of NFPAs. |
format | Online Article Text |
id | pubmed-7544428 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-75444282020-10-30 Hyperprolactinemia in clinical non-functional pituitary macroadenomas: A STROBE-compliant study Lyu, Liang Yin, Senlin Hu, Yu Chen, Cheng Jiang, Yong Yu, Yang Ma, Weichao Wang, Zeming Jiang, Shu Zhou, Peizhi Medicine (Baltimore) 7100 Hyperprolactinemia is a prevalent endocrine disorder presented in patients with non-functional pituitary adenomas (NFPAs). However, the mechanism involved in hyperprolactinemia in NFPA is not fully illustrated. The current study aims to investigate predictors for hyperprolactinemia in NFPA via analyzing relevant clinical features. Thus, in this study, a cohort of 214 cases with integrated medical records was retrospectively analyzed concerning clinical, pathological, and endocrinological studies before and after surgery. Hyperprolactinemia happened in 93 cases (43.5%). Women (adjust odds ratio [OR] = 3.093; P < .01), age of patients (adjust OR = 0.951; P < .01), and serum free tetraiodothyronine (FT4) level (adjust OR = 0.882; P = .02) were independent predictors for developing preoperative hyperprolactinemia. Tumor size and hypopituitarism had no impact on hyperprolactinemia. During a median follow-up of 43.5 (range, 22–80) months, 83.9% patients with preoperative hyperprolactinemia experienced prolactin (PRL) normalization. Preoperative PRL level (adjusted OR = 1.741, P = .03) was the exclusive predictor for PRL normalization after adjusting for tumor volume, preoperative serum FT4 concentration, and postoperative residual. The PRL normalization rate of patients with lower PRL level (<2.35-fold upper limit of normal range) was 95.2% and decreased to 65.5% for patients with higher PRL level. In conclusion, our results suggest existence of potentially alternative mechanisms underlying hyperprolactinemia in NFPAs, like the discrepancy of sex and age and the negative feedback of FT4. Preoperative PRL is a predictor for postoperative PRL normalization, which is of clinically relevant for postoperative management of NFPAs. Lippincott Williams & Wilkins 2020-10-09 /pmc/articles/PMC7544428/ /pubmed/33031334 http://dx.doi.org/10.1097/MD.0000000000022673 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | 7100 Lyu, Liang Yin, Senlin Hu, Yu Chen, Cheng Jiang, Yong Yu, Yang Ma, Weichao Wang, Zeming Jiang, Shu Zhou, Peizhi Hyperprolactinemia in clinical non-functional pituitary macroadenomas: A STROBE-compliant study |
title | Hyperprolactinemia in clinical non-functional pituitary macroadenomas: A STROBE-compliant study |
title_full | Hyperprolactinemia in clinical non-functional pituitary macroadenomas: A STROBE-compliant study |
title_fullStr | Hyperprolactinemia in clinical non-functional pituitary macroadenomas: A STROBE-compliant study |
title_full_unstemmed | Hyperprolactinemia in clinical non-functional pituitary macroadenomas: A STROBE-compliant study |
title_short | Hyperprolactinemia in clinical non-functional pituitary macroadenomas: A STROBE-compliant study |
title_sort | hyperprolactinemia in clinical non-functional pituitary macroadenomas: a strobe-compliant study |
topic | 7100 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544428/ https://www.ncbi.nlm.nih.gov/pubmed/33031334 http://dx.doi.org/10.1097/MD.0000000000022673 |
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