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Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication

OBJECTIVES: The aims of this study are to assess different saliva substitutes for their efficacy to lubricate the oral cavity, and to relate this oral lubrication to the ability of saliva substitutes to adsorb on and change the structure of the existing salivary conditioning film (SCF). MATERIALS AN...

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Autores principales: Vinke, Jeroen, Kaper, Hans J., Vissink, Arjan, Sharma, Prashant K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544715/
https://www.ncbi.nlm.nih.gov/pubmed/32303864
http://dx.doi.org/10.1007/s00784-020-03272-x
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author Vinke, Jeroen
Kaper, Hans J.
Vissink, Arjan
Sharma, Prashant K.
author_facet Vinke, Jeroen
Kaper, Hans J.
Vissink, Arjan
Sharma, Prashant K.
author_sort Vinke, Jeroen
collection PubMed
description OBJECTIVES: The aims of this study are to assess different saliva substitutes for their efficacy to lubricate the oral cavity, and to relate this oral lubrication to the ability of saliva substitutes to adsorb on and change the structure of the existing salivary conditioning film (SCF). MATERIALS AND METHODS: Quartz crystal microbalance with dissipation was used to study the capability of saliva substitutes to interact with natural SCF and the ability to change the secondary SCF (S-SCF). A tongue-enamel friction system mimicking xerostomic conditions was used to assess the relief and relief period expected from these substitutes under set circumstances. RESULTS: Saliva Orthana spray, Biotène spray and Gum Hydral gel had an immediate effect on a SCF, increasing its structural softness. BioXtra gel, Biotène gel, Gum Hydral gel and Glandosane spray changed the S-SCF by increasing salivary protein adsorption, while others showed no sign of interaction. With respect to relief, only 2 out of the 16 saliva substitutes tested (Saliva Orthana spray and Gum Hydral gel) performed better than water. Overall, relief period correlated positively to structural softness change, whereas a positive correlation was seen between relief and mass adsorption. CONCLUSIONS: The majority of saliva substitutes did not adsorb on the SCF, thus did not enhance lubrication. Only saliva substitutes containing carrageenan, carboxymethylcellulose, pig gastric mucin, xanthan gum and carbomer performed better in enhancing oral lubrication. CLINICAL RELEVANCE: This objective assessment will help clinicians and patients make better choice of saliva substitutes. This study provides a scientific basis for future improvement in saliva substitutes.
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spelling pubmed-75447152020-10-19 Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication Vinke, Jeroen Kaper, Hans J. Vissink, Arjan Sharma, Prashant K. Clin Oral Investig Original Article OBJECTIVES: The aims of this study are to assess different saliva substitutes for their efficacy to lubricate the oral cavity, and to relate this oral lubrication to the ability of saliva substitutes to adsorb on and change the structure of the existing salivary conditioning film (SCF). MATERIALS AND METHODS: Quartz crystal microbalance with dissipation was used to study the capability of saliva substitutes to interact with natural SCF and the ability to change the secondary SCF (S-SCF). A tongue-enamel friction system mimicking xerostomic conditions was used to assess the relief and relief period expected from these substitutes under set circumstances. RESULTS: Saliva Orthana spray, Biotène spray and Gum Hydral gel had an immediate effect on a SCF, increasing its structural softness. BioXtra gel, Biotène gel, Gum Hydral gel and Glandosane spray changed the S-SCF by increasing salivary protein adsorption, while others showed no sign of interaction. With respect to relief, only 2 out of the 16 saliva substitutes tested (Saliva Orthana spray and Gum Hydral gel) performed better than water. Overall, relief period correlated positively to structural softness change, whereas a positive correlation was seen between relief and mass adsorption. CONCLUSIONS: The majority of saliva substitutes did not adsorb on the SCF, thus did not enhance lubrication. Only saliva substitutes containing carrageenan, carboxymethylcellulose, pig gastric mucin, xanthan gum and carbomer performed better in enhancing oral lubrication. CLINICAL RELEVANCE: This objective assessment will help clinicians and patients make better choice of saliva substitutes. This study provides a scientific basis for future improvement in saliva substitutes. Springer Berlin Heidelberg 2020-04-17 2020 /pmc/articles/PMC7544715/ /pubmed/32303864 http://dx.doi.org/10.1007/s00784-020-03272-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Vinke, Jeroen
Kaper, Hans J.
Vissink, Arjan
Sharma, Prashant K.
Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication
title Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication
title_full Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication
title_fullStr Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication
title_full_unstemmed Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication
title_short Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication
title_sort dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544715/
https://www.ncbi.nlm.nih.gov/pubmed/32303864
http://dx.doi.org/10.1007/s00784-020-03272-x
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