Cargando…

Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study

BACKGROUND: Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. Previous studies on the association of Val66Met with whole hippocampal volume included patients of a variety of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vilor-Tejedor, Natalia, Operto, Grégory, Evans, Tavia E., Falcon, Carles, Crous-Bou, Marta, Minguillón, Carolina, Cacciaglia, Raffaele, Milà-Alomà, Marta, Grau-Rivera, Oriol, Suárez-Calvet, Marc, Garrido-Martín, Diego, Morán, Sebastián, Esteller, Manel, Adams, Hieab H., Molinuevo, José Luis, Guigó, Roderic, Gispert, Juan Domingo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544723/ https://www.ncbi.nlm.nih.gov/pubmed/32804326 http://dx.doi.org/10.1007/s00429-020-02125-3

Ejemplares similares

Genetic Influences on Hippocampal Subfields: An Emerging Area of Neuroscience Research
por: Vilor-Tejedor, Natalia, et al.
Publicado: (2021)

Genetic Predisposition to Alzheimer’s Disease Is Associated with Enlargement of Perivascular Spaces in Centrum Semiovale Region
por: Ciampa, Iacopo, et al.
Publicado: (2021)

Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer’s continuum
por: Vilor-Tejedor, Natalia, et al.
Publicado: (2021)

APOE-ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals
por: Brugulat-Serrat, Anna, et al.
Publicado: (2023)

Prediction of amyloid pathology in cognitively unimpaired individuals using voxel-wise analysis of longitudinal structural brain MRI
por: Petrone, Paula M., et al.
Publicado: (2019)

Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults
por: Grau-Rivera, Oriol, et al.
Publicado: (2020)

Cognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF biomarker profile
por: Milà-Alomà, Marta, et al.
Publicado: (2021)

White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants
por: Brugulat‐Serrat, Anna, et al.
Publicado: (2019)

Genetically predicted telomere length and its relationship with neurodegenerative diseases and life expectancy
por: Rodríguez-Fernández, Blanca, et al.
Publicado: (2022)

The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals
por: Salvadó, Gemma, et al.
Publicado: (2021)

Brain correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk for Alzheimer's disease: A study on Barcelona's population
por: Falcón, Carles, et al.
Publicado: (2021)

Quantitative informant‐ and self‐reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4
por: Sánchez‐Benavides, Gonzalo, et al.
Publicado: (2020)

Cross-sectional and longitudinal association of sleep and Alzheimer biomarkers in cognitively unimpaired adults
por: Blackman, Jonathan, et al.
Publicado: (2022)

Prepandemic Alzheimer Disease Biomarkers and Anxious-Depressive Symptoms During the COVID-19 Confinement in Cognitively Unimpaired Adults
por: Akinci, Muge, et al.
Publicado: (2022)

Multivariate Analysis and Modelling of multiple Brain endOphenotypes: Let’s MAMBO!
por: Vilor-Tejedor, Natalia, et al.
Publicado: (2021)

DHA intake relates to better cerebrovascular and neurodegeneration neuroimaging phenotypes in middle-aged adults at increased genetic risk of Alzheimer disease
por: Sala-Vila, Aleix, et al.
Publicado: (2021)

The ALFA project: A research platform to identify early pathophysiological features of Alzheimer's disease
por: Molinuevo, José Luis, et al.
Publicado: (2016)

Genotypic effects of APOE-ε4 on resting-state connectivity in cognitively intact individuals support functional brain compensation
por: Cacciaglia, Raffaele, et al.
Publicado: (2022)

Brain alterations in the early Alzheimer’s continuum with amyloid-β, tau, glial and neurodegeneration CSF markers
por: Salvadó, Gemma, et al.
Publicado: (2022)

Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects
por: Operto, Grégory, et al.
Publicado: (2019)

Age, sex and APOE-ε4 modify the balance between soluble and fibrillar β-amyloid in non-demented individuals: topographical patterns across two independent cohorts
por: Cacciaglia, Raffaele, et al.
Publicado: (2022)

Longitudinal structural cerebral changes related to core CSF biomarkers in preclinical Alzheimer's disease: A study of two independent datasets
por: Falcon, Carles, et al.
Publicado: (2018)

White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes
por: Operto, Grégory, et al.
Publicado: (2018)

Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer’s continuum
por: Salvadó, Gemma, et al.
Publicado: (2022)

NeAT: a Nonlinear Analysis Toolbox for Neuroimaging
por: Casamitjana, Adrià, et al.
Publicado: (2020)

Genetically predicted telomere length and Alzheimer’s disease endophenotypes: a Mendelian randomization study
por: Rodríguez-Fernández, Blanca, et al.
Publicado: (2022)

Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum
por: Milà‐Alomà, Marta, et al.
Publicado: (2020)

Brain and cognitive correlates of subjective cognitive decline-plus features in a population-based cohort
por: Sánchez-Benavides, Gonzalo, et al.
Publicado: (2018)

Nonlinear interaction between APOE ε4 allele load and age in the hippocampal surface of cognitively intact individuals
por: Martí‐Juan, Gerard, et al.
Publicado: (2020)

Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders
por: Sadeghi, Iman, et al.
Publicado: (2022)

Distinct Cognitive and Brain Morphological Features in Healthy Subjects Unaware of Informant-Reported Cognitive Decline
por: Sánchez-Benavides, Gonzalo, et al.
Publicado: (2018)

CSF glial biomarkers YKL40 and sTREM2 are associated with longitudinal volume and diffusivity changes in cognitively unimpaired individuals
por: Falcon, Carles, et al.
Publicado: (2019)

APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals
por: Cacciaglia, Raffaele, et al.
Publicado: (2019)

Alzheimer’s disease prevention: from risk factors to early intervention
por: Crous-Bou, Marta, et al.
Publicado: (2017)

CSF Synaptic Biomarkers in the Preclinical Stage of Alzheimer Disease and Their Association With MRI and PET: A Cross-sectional Study
por: Milà-Alomà, Marta, et al.
Publicado: (2021)

Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: a cross-sectional analysis from the ALFA (Alzheimer and Families) project
por: Brugulat-Serrat, Anna, et al.
Publicado: (2017)

Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer’s disease and neurodegeneration stratified by sex
por: Cumplido-Mayoral, Irene, et al.
Publicado: (2023)

Episodic memory and executive functions in cognitively healthy individuals display distinct neuroanatomical correlates which are differentially modulated by aging
por: Cacciaglia, Raffaele, et al.
Publicado: (2018)

Management and Quality Control of Large Neuroimaging Datasets: Developments From the Barcelonaβeta Brain Research Center
por: Huguet, Jordi, et al.
Publicado: (2021)

The Rationale Behind the New Alzheimer’s Disease Conceptualization: Lessons Learned During the Last Decades
por: Molinuevo, José Luis, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ei4uoastrjgfeilsqlgvl58d7k