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SOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses
The host immune system has multiple innate immune receptors that can identify, distinguish and react to viral infections. In innate immune response, the host recognizes pathogen-associated molecular patterns (PAMP) in nucleic acids or viral proteins through pathogen recognition receptors (PRRs), esp...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544739/ https://www.ncbi.nlm.nih.gov/pubmed/33072096 http://dx.doi.org/10.3389/fimmu.2020.558341 |
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author | Huang, Shanzhi Liu, Ke Cheng, Anchun Wang, Mingshu Cui, Min Huang, Juan Zhu, Dekang Chen, Shun Liu, Mafeng Zhao, Xinxin Wu, Yin Yang, Qiao Zhang, Shaqiu Ou, Xumin Mao, Sai Gao, Qun Yu, Yanling Tian, Bin Liu, Yunya Zhang, Ling Yin, Zhongqiong Jing, Bo Chen, Xiaoyue Jia, Renyong |
author_facet | Huang, Shanzhi Liu, Ke Cheng, Anchun Wang, Mingshu Cui, Min Huang, Juan Zhu, Dekang Chen, Shun Liu, Mafeng Zhao, Xinxin Wu, Yin Yang, Qiao Zhang, Shaqiu Ou, Xumin Mao, Sai Gao, Qun Yu, Yanling Tian, Bin Liu, Yunya Zhang, Ling Yin, Zhongqiong Jing, Bo Chen, Xiaoyue Jia, Renyong |
author_sort | Huang, Shanzhi |
collection | PubMed |
description | The host immune system has multiple innate immune receptors that can identify, distinguish and react to viral infections. In innate immune response, the host recognizes pathogen-associated molecular patterns (PAMP) in nucleic acids or viral proteins through pathogen recognition receptors (PRRs), especially toll-like receptors (TLRs) and induces immune cells or infected cells to produce type I Interferons (IFN-I) and pro-inflammatory cytokines, thus when the virus invades the host, innate immunity is the earliest immune mechanism. Besides, cytokine-mediated cell communication is necessary for the proper regulation of immune responses. Therefore, the appropriate activation of innate immunity is necessary for the normal life activities of cells. The suppressor of the cytokine signaling proteins (SOCS) family is one of the main regulators of the innate immune response induced by microbial pathogens. They mainly participate in the negative feedback regulation of cytokine signal transduction through Janus kinase signal transducer and transcriptional activator (JAK/STAT) and other signal pathways. Taken together, this paper reviews the SOCS proteins structures and the function of each domain, as well as the latest knowledge of the role of SOCS proteins in innate immune caused by viral infections and the mechanisms by which SOCS proteins assist viruses to escape host innate immunity. Finally, we discuss potential values of these proteins in future targeted therapies. |
format | Online Article Text |
id | pubmed-7544739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75447392020-10-17 SOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses Huang, Shanzhi Liu, Ke Cheng, Anchun Wang, Mingshu Cui, Min Huang, Juan Zhu, Dekang Chen, Shun Liu, Mafeng Zhao, Xinxin Wu, Yin Yang, Qiao Zhang, Shaqiu Ou, Xumin Mao, Sai Gao, Qun Yu, Yanling Tian, Bin Liu, Yunya Zhang, Ling Yin, Zhongqiong Jing, Bo Chen, Xiaoyue Jia, Renyong Front Immunol Immunology The host immune system has multiple innate immune receptors that can identify, distinguish and react to viral infections. In innate immune response, the host recognizes pathogen-associated molecular patterns (PAMP) in nucleic acids or viral proteins through pathogen recognition receptors (PRRs), especially toll-like receptors (TLRs) and induces immune cells or infected cells to produce type I Interferons (IFN-I) and pro-inflammatory cytokines, thus when the virus invades the host, innate immunity is the earliest immune mechanism. Besides, cytokine-mediated cell communication is necessary for the proper regulation of immune responses. Therefore, the appropriate activation of innate immunity is necessary for the normal life activities of cells. The suppressor of the cytokine signaling proteins (SOCS) family is one of the main regulators of the innate immune response induced by microbial pathogens. They mainly participate in the negative feedback regulation of cytokine signal transduction through Janus kinase signal transducer and transcriptional activator (JAK/STAT) and other signal pathways. Taken together, this paper reviews the SOCS proteins structures and the function of each domain, as well as the latest knowledge of the role of SOCS proteins in innate immune caused by viral infections and the mechanisms by which SOCS proteins assist viruses to escape host innate immunity. Finally, we discuss potential values of these proteins in future targeted therapies. Frontiers Media S.A. 2020-09-25 /pmc/articles/PMC7544739/ /pubmed/33072096 http://dx.doi.org/10.3389/fimmu.2020.558341 Text en Copyright © 2020 Huang, Liu, Cheng, Wang, Cui, Huang, Zhu, Chen, Liu, Zhao, Wu, Yang, Zhang, Ou, Mao, Gao, Yu, Tian, Liu, Zhang, Yin, Jing, Chen and Jia. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Huang, Shanzhi Liu, Ke Cheng, Anchun Wang, Mingshu Cui, Min Huang, Juan Zhu, Dekang Chen, Shun Liu, Mafeng Zhao, Xinxin Wu, Yin Yang, Qiao Zhang, Shaqiu Ou, Xumin Mao, Sai Gao, Qun Yu, Yanling Tian, Bin Liu, Yunya Zhang, Ling Yin, Zhongqiong Jing, Bo Chen, Xiaoyue Jia, Renyong SOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses |
title | SOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses |
title_full | SOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses |
title_fullStr | SOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses |
title_full_unstemmed | SOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses |
title_short | SOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses |
title_sort | socs proteins participate in the regulation of innate immune response caused by viruses |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544739/ https://www.ncbi.nlm.nih.gov/pubmed/33072096 http://dx.doi.org/10.3389/fimmu.2020.558341 |
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