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SOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses

The host immune system has multiple innate immune receptors that can identify, distinguish and react to viral infections. In innate immune response, the host recognizes pathogen-associated molecular patterns (PAMP) in nucleic acids or viral proteins through pathogen recognition receptors (PRRs), esp...

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Autores principales: Huang, Shanzhi, Liu, Ke, Cheng, Anchun, Wang, Mingshu, Cui, Min, Huang, Juan, Zhu, Dekang, Chen, Shun, Liu, Mafeng, Zhao, Xinxin, Wu, Yin, Yang, Qiao, Zhang, Shaqiu, Ou, Xumin, Mao, Sai, Gao, Qun, Yu, Yanling, Tian, Bin, Liu, Yunya, Zhang, Ling, Yin, Zhongqiong, Jing, Bo, Chen, Xiaoyue, Jia, Renyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544739/
https://www.ncbi.nlm.nih.gov/pubmed/33072096
http://dx.doi.org/10.3389/fimmu.2020.558341
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author Huang, Shanzhi
Liu, Ke
Cheng, Anchun
Wang, Mingshu
Cui, Min
Huang, Juan
Zhu, Dekang
Chen, Shun
Liu, Mafeng
Zhao, Xinxin
Wu, Yin
Yang, Qiao
Zhang, Shaqiu
Ou, Xumin
Mao, Sai
Gao, Qun
Yu, Yanling
Tian, Bin
Liu, Yunya
Zhang, Ling
Yin, Zhongqiong
Jing, Bo
Chen, Xiaoyue
Jia, Renyong
author_facet Huang, Shanzhi
Liu, Ke
Cheng, Anchun
Wang, Mingshu
Cui, Min
Huang, Juan
Zhu, Dekang
Chen, Shun
Liu, Mafeng
Zhao, Xinxin
Wu, Yin
Yang, Qiao
Zhang, Shaqiu
Ou, Xumin
Mao, Sai
Gao, Qun
Yu, Yanling
Tian, Bin
Liu, Yunya
Zhang, Ling
Yin, Zhongqiong
Jing, Bo
Chen, Xiaoyue
Jia, Renyong
author_sort Huang, Shanzhi
collection PubMed
description The host immune system has multiple innate immune receptors that can identify, distinguish and react to viral infections. In innate immune response, the host recognizes pathogen-associated molecular patterns (PAMP) in nucleic acids or viral proteins through pathogen recognition receptors (PRRs), especially toll-like receptors (TLRs) and induces immune cells or infected cells to produce type I Interferons (IFN-I) and pro-inflammatory cytokines, thus when the virus invades the host, innate immunity is the earliest immune mechanism. Besides, cytokine-mediated cell communication is necessary for the proper regulation of immune responses. Therefore, the appropriate activation of innate immunity is necessary for the normal life activities of cells. The suppressor of the cytokine signaling proteins (SOCS) family is one of the main regulators of the innate immune response induced by microbial pathogens. They mainly participate in the negative feedback regulation of cytokine signal transduction through Janus kinase signal transducer and transcriptional activator (JAK/STAT) and other signal pathways. Taken together, this paper reviews the SOCS proteins structures and the function of each domain, as well as the latest knowledge of the role of SOCS proteins in innate immune caused by viral infections and the mechanisms by which SOCS proteins assist viruses to escape host innate immunity. Finally, we discuss potential values of these proteins in future targeted therapies.
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spelling pubmed-75447392020-10-17 SOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses Huang, Shanzhi Liu, Ke Cheng, Anchun Wang, Mingshu Cui, Min Huang, Juan Zhu, Dekang Chen, Shun Liu, Mafeng Zhao, Xinxin Wu, Yin Yang, Qiao Zhang, Shaqiu Ou, Xumin Mao, Sai Gao, Qun Yu, Yanling Tian, Bin Liu, Yunya Zhang, Ling Yin, Zhongqiong Jing, Bo Chen, Xiaoyue Jia, Renyong Front Immunol Immunology The host immune system has multiple innate immune receptors that can identify, distinguish and react to viral infections. In innate immune response, the host recognizes pathogen-associated molecular patterns (PAMP) in nucleic acids or viral proteins through pathogen recognition receptors (PRRs), especially toll-like receptors (TLRs) and induces immune cells or infected cells to produce type I Interferons (IFN-I) and pro-inflammatory cytokines, thus when the virus invades the host, innate immunity is the earliest immune mechanism. Besides, cytokine-mediated cell communication is necessary for the proper regulation of immune responses. Therefore, the appropriate activation of innate immunity is necessary for the normal life activities of cells. The suppressor of the cytokine signaling proteins (SOCS) family is one of the main regulators of the innate immune response induced by microbial pathogens. They mainly participate in the negative feedback regulation of cytokine signal transduction through Janus kinase signal transducer and transcriptional activator (JAK/STAT) and other signal pathways. Taken together, this paper reviews the SOCS proteins structures and the function of each domain, as well as the latest knowledge of the role of SOCS proteins in innate immune caused by viral infections and the mechanisms by which SOCS proteins assist viruses to escape host innate immunity. Finally, we discuss potential values of these proteins in future targeted therapies. Frontiers Media S.A. 2020-09-25 /pmc/articles/PMC7544739/ /pubmed/33072096 http://dx.doi.org/10.3389/fimmu.2020.558341 Text en Copyright © 2020 Huang, Liu, Cheng, Wang, Cui, Huang, Zhu, Chen, Liu, Zhao, Wu, Yang, Zhang, Ou, Mao, Gao, Yu, Tian, Liu, Zhang, Yin, Jing, Chen and Jia. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Huang, Shanzhi
Liu, Ke
Cheng, Anchun
Wang, Mingshu
Cui, Min
Huang, Juan
Zhu, Dekang
Chen, Shun
Liu, Mafeng
Zhao, Xinxin
Wu, Yin
Yang, Qiao
Zhang, Shaqiu
Ou, Xumin
Mao, Sai
Gao, Qun
Yu, Yanling
Tian, Bin
Liu, Yunya
Zhang, Ling
Yin, Zhongqiong
Jing, Bo
Chen, Xiaoyue
Jia, Renyong
SOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses
title SOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses
title_full SOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses
title_fullStr SOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses
title_full_unstemmed SOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses
title_short SOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses
title_sort socs proteins participate in the regulation of innate immune response caused by viruses
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544739/
https://www.ncbi.nlm.nih.gov/pubmed/33072096
http://dx.doi.org/10.3389/fimmu.2020.558341
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