Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants

Adjuvants are added to vaccines to enhance the immune response and provide increased protection against disease. In the last decade, hundreds of synthetic immune adjuvants have been created, but many induce undesirable levels of proinflammatory cytokines including TNF-α and IL-6. Here we present sma...

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Autores principales: Moser, Brittany A., Escalante-Buendia, Yoseline, Steinhardt, Rachel C., Rosenberger, Matthew G., Cassaidy, Britteny J., Naorem, Nihesh, Chon, Alfred C., Nguyen, Minh H., Tran, Ngoctran T., Esser-Kahn, Aaron P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544742/
https://www.ncbi.nlm.nih.gov/pubmed/33072085
http://dx.doi.org/10.3389/fimmu.2020.511513
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author Moser, Brittany A.
Escalante-Buendia, Yoseline
Steinhardt, Rachel C.
Rosenberger, Matthew G.
Cassaidy, Britteny J.
Naorem, Nihesh
Chon, Alfred C.
Nguyen, Minh H.
Tran, Ngoctran T.
Esser-Kahn, Aaron P.
author_facet Moser, Brittany A.
Escalante-Buendia, Yoseline
Steinhardt, Rachel C.
Rosenberger, Matthew G.
Cassaidy, Britteny J.
Naorem, Nihesh
Chon, Alfred C.
Nguyen, Minh H.
Tran, Ngoctran T.
Esser-Kahn, Aaron P.
author_sort Moser, Brittany A.
collection PubMed
description Adjuvants are added to vaccines to enhance the immune response and provide increased protection against disease. In the last decade, hundreds of synthetic immune adjuvants have been created, but many induce undesirable levels of proinflammatory cytokines including TNF-α and IL-6. Here we present small molecule NF-κB inhibitors that can be used in combination with an immune adjuvant to both decrease markers associated with poor tolerability and improve the protective response of vaccination. Additionally, we synthesize a library of honokiol derivatives identifying several promising candidates for use in vaccine formulations.
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spelling pubmed-75447422020-10-17 Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants Moser, Brittany A. Escalante-Buendia, Yoseline Steinhardt, Rachel C. Rosenberger, Matthew G. Cassaidy, Britteny J. Naorem, Nihesh Chon, Alfred C. Nguyen, Minh H. Tran, Ngoctran T. Esser-Kahn, Aaron P. Front Immunol Immunology Adjuvants are added to vaccines to enhance the immune response and provide increased protection against disease. In the last decade, hundreds of synthetic immune adjuvants have been created, but many induce undesirable levels of proinflammatory cytokines including TNF-α and IL-6. Here we present small molecule NF-κB inhibitors that can be used in combination with an immune adjuvant to both decrease markers associated with poor tolerability and improve the protective response of vaccination. Additionally, we synthesize a library of honokiol derivatives identifying several promising candidates for use in vaccine formulations. Frontiers Media S.A. 2020-09-25 /pmc/articles/PMC7544742/ /pubmed/33072085 http://dx.doi.org/10.3389/fimmu.2020.511513 Text en Copyright © 2020 Moser, Escalante-Buendia, Steinhardt, Rosenberger, Cassaidy, Naorem, Chon, Nguyen, Tran and Esser-Kahn. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Moser, Brittany A.
Escalante-Buendia, Yoseline
Steinhardt, Rachel C.
Rosenberger, Matthew G.
Cassaidy, Britteny J.
Naorem, Nihesh
Chon, Alfred C.
Nguyen, Minh H.
Tran, Ngoctran T.
Esser-Kahn, Aaron P.
Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants
title Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants
title_full Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants
title_fullStr Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants
title_full_unstemmed Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants
title_short Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants
title_sort small molecule nf-κb inhibitors as immune potentiators for enhancement of vaccine adjuvants
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544742/
https://www.ncbi.nlm.nih.gov/pubmed/33072085
http://dx.doi.org/10.3389/fimmu.2020.511513
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