Oxytocin Receptor Signaling in Vascular Function and Stroke

The oxytocin receptor (OXTR) is a G protein-coupled receptor with a diverse repertoire of intracellular signaling pathways, which are activated in response to binding oxytocin (OXT) and a similar nonapeptide, vasopressin. This review summarizes the cell and molecular biology of the OXTR and its down...

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Detalles Bibliográficos
Autores principales: McKay, Erin C., Counts, Scott E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544744/
https://www.ncbi.nlm.nih.gov/pubmed/33071746
http://dx.doi.org/10.3389/fnins.2020.574499
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author McKay, Erin C.
Counts, Scott E.
author_facet McKay, Erin C.
Counts, Scott E.
author_sort McKay, Erin C.
collection PubMed
description The oxytocin receptor (OXTR) is a G protein-coupled receptor with a diverse repertoire of intracellular signaling pathways, which are activated in response to binding oxytocin (OXT) and a similar nonapeptide, vasopressin. This review summarizes the cell and molecular biology of the OXTR and its downstream signaling cascades, particularly focusing on the vasoactive functions of OXTR signaling in humans and animal models, as well as the clinical applications of OXTR targeting cerebrovascular accidents.
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spelling pubmed-75447442020-10-17 Oxytocin Receptor Signaling in Vascular Function and Stroke McKay, Erin C. Counts, Scott E. Front Neurosci Neuroscience The oxytocin receptor (OXTR) is a G protein-coupled receptor with a diverse repertoire of intracellular signaling pathways, which are activated in response to binding oxytocin (OXT) and a similar nonapeptide, vasopressin. This review summarizes the cell and molecular biology of the OXTR and its downstream signaling cascades, particularly focusing on the vasoactive functions of OXTR signaling in humans and animal models, as well as the clinical applications of OXTR targeting cerebrovascular accidents. Frontiers Media S.A. 2020-09-25 /pmc/articles/PMC7544744/ /pubmed/33071746 http://dx.doi.org/10.3389/fnins.2020.574499 Text en Copyright © 2020 McKay and Counts. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
McKay, Erin C.
Counts, Scott E.
Oxytocin Receptor Signaling in Vascular Function and Stroke
title Oxytocin Receptor Signaling in Vascular Function and Stroke
title_full Oxytocin Receptor Signaling in Vascular Function and Stroke
title_fullStr Oxytocin Receptor Signaling in Vascular Function and Stroke
title_full_unstemmed Oxytocin Receptor Signaling in Vascular Function and Stroke
title_short Oxytocin Receptor Signaling in Vascular Function and Stroke
title_sort oxytocin receptor signaling in vascular function and stroke
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544744/
https://www.ncbi.nlm.nih.gov/pubmed/33071746
http://dx.doi.org/10.3389/fnins.2020.574499
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