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Optical Coherence Tomography Angiography in Macular Neovascularization: A Comparison Between Different OCTA Devices

PURPOSE: The purpose of this study is to compare the ability of 3 optical coherence tomography angiography (OCTA) devices to measure lesion area in patients with macular neovascularization (MNV) with type 1, 2 and mixed neovascularization (NV). METHODS: OCTA, fluorescein angiography (FA), indocyanin...

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Autores principales: Mastropasqua, Rodolfo, Evangelista, Federica, Amodei, Francesco, D'Aloisio, Rossella, Pinto, Filomena, Doronzo, Emanuele, Viggiano, Pasquale, Porreca, Annamaria, Di Nicola, Marta, Parravano, Mariacristina, Toto, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545059/
https://www.ncbi.nlm.nih.gov/pubmed/33101783
http://dx.doi.org/10.1167/tvst.9.11.6
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author Mastropasqua, Rodolfo
Evangelista, Federica
Amodei, Francesco
D'Aloisio, Rossella
Pinto, Filomena
Doronzo, Emanuele
Viggiano, Pasquale
Porreca, Annamaria
Di Nicola, Marta
Parravano, Mariacristina
Toto, Lisa
author_facet Mastropasqua, Rodolfo
Evangelista, Federica
Amodei, Francesco
D'Aloisio, Rossella
Pinto, Filomena
Doronzo, Emanuele
Viggiano, Pasquale
Porreca, Annamaria
Di Nicola, Marta
Parravano, Mariacristina
Toto, Lisa
author_sort Mastropasqua, Rodolfo
collection PubMed
description PURPOSE: The purpose of this study is to compare the ability of 3 optical coherence tomography angiography (OCTA) devices to measure lesion area in patients with macular neovascularization (MNV) with type 1, 2 and mixed neovascularization (NV). METHODS: OCTA, fluorescein angiography (FA), indocyanine green angiography (ICGA), and structural optical coherence tomography (OCT) were performed. NV lesion area measurements were performed by two graders. RESULTS: Twenty-eight eyes were included: 20 with NV were classified as type 1, 6 as type 2, and 2 as mixed type. AngioVue and Spectralis detected the NV in 26 out of 28 eyes (92.8%). The intraclass correlation coefficient (ICC) between readers for the three different OCTA with the different slabs was high. The NV area was larger in the outer retina to choriocapillaris (ORCC) and choriocapillaris (CC) images for the AngioVue device and the PLEX Elite device compared to avascular images (P < 0.05). The mean values of the NV area were not significantly different among the three instruments (Friedman test, P > 0.05) for the avascular zone (AV), ORCC, and CC images. Median (interquartile range [IQR]) NV were significantly different among avascular images, ORCC images, and CC images of the AngioVue device (P = 0.046), of the Spectralis device (P = 0.015), and the PLEX Elite device (P < 0.001). CONCLUSIONS: The ORCC slabs showed the highest detection rate for NV detection independently to the device used, and swept source (SS)-OCTA measurements of ORCC slabs showed the highest detection rate of NVs compared to the spectral domain (SD)-OCTA. TRANSLATIONAL RELEVANCE: It is pivotal to realize how much we can rely on OCTA to make a diagnosis of NV.
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spelling pubmed-75450592020-10-23 Optical Coherence Tomography Angiography in Macular Neovascularization: A Comparison Between Different OCTA Devices Mastropasqua, Rodolfo Evangelista, Federica Amodei, Francesco D'Aloisio, Rossella Pinto, Filomena Doronzo, Emanuele Viggiano, Pasquale Porreca, Annamaria Di Nicola, Marta Parravano, Mariacristina Toto, Lisa Transl Vis Sci Technol Article PURPOSE: The purpose of this study is to compare the ability of 3 optical coherence tomography angiography (OCTA) devices to measure lesion area in patients with macular neovascularization (MNV) with type 1, 2 and mixed neovascularization (NV). METHODS: OCTA, fluorescein angiography (FA), indocyanine green angiography (ICGA), and structural optical coherence tomography (OCT) were performed. NV lesion area measurements were performed by two graders. RESULTS: Twenty-eight eyes were included: 20 with NV were classified as type 1, 6 as type 2, and 2 as mixed type. AngioVue and Spectralis detected the NV in 26 out of 28 eyes (92.8%). The intraclass correlation coefficient (ICC) between readers for the three different OCTA with the different slabs was high. The NV area was larger in the outer retina to choriocapillaris (ORCC) and choriocapillaris (CC) images for the AngioVue device and the PLEX Elite device compared to avascular images (P < 0.05). The mean values of the NV area were not significantly different among the three instruments (Friedman test, P > 0.05) for the avascular zone (AV), ORCC, and CC images. Median (interquartile range [IQR]) NV were significantly different among avascular images, ORCC images, and CC images of the AngioVue device (P = 0.046), of the Spectralis device (P = 0.015), and the PLEX Elite device (P < 0.001). CONCLUSIONS: The ORCC slabs showed the highest detection rate for NV detection independently to the device used, and swept source (SS)-OCTA measurements of ORCC slabs showed the highest detection rate of NVs compared to the spectral domain (SD)-OCTA. TRANSLATIONAL RELEVANCE: It is pivotal to realize how much we can rely on OCTA to make a diagnosis of NV. The Association for Research in Vision and Ophthalmology 2020-10-07 /pmc/articles/PMC7545059/ /pubmed/33101783 http://dx.doi.org/10.1167/tvst.9.11.6 Text en Copyright 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Article
Mastropasqua, Rodolfo
Evangelista, Federica
Amodei, Francesco
D'Aloisio, Rossella
Pinto, Filomena
Doronzo, Emanuele
Viggiano, Pasquale
Porreca, Annamaria
Di Nicola, Marta
Parravano, Mariacristina
Toto, Lisa
Optical Coherence Tomography Angiography in Macular Neovascularization: A Comparison Between Different OCTA Devices
title Optical Coherence Tomography Angiography in Macular Neovascularization: A Comparison Between Different OCTA Devices
title_full Optical Coherence Tomography Angiography in Macular Neovascularization: A Comparison Between Different OCTA Devices
title_fullStr Optical Coherence Tomography Angiography in Macular Neovascularization: A Comparison Between Different OCTA Devices
title_full_unstemmed Optical Coherence Tomography Angiography in Macular Neovascularization: A Comparison Between Different OCTA Devices
title_short Optical Coherence Tomography Angiography in Macular Neovascularization: A Comparison Between Different OCTA Devices
title_sort optical coherence tomography angiography in macular neovascularization: a comparison between different octa devices
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545059/
https://www.ncbi.nlm.nih.gov/pubmed/33101783
http://dx.doi.org/10.1167/tvst.9.11.6
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