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Mitochondrial Transfer of the Mutant Human ND6T14484C Gene Causes Visual Loss and Optic Neuropathy

PURPOSE: To evaluate the long-term effects of mitochondrial gene transfer of mutant human NADH ubiquinone oxidoreductase subunit VI (hND6T14484C) in the mouse eye. METHODS: Adult mice were injected intravitreally with mitochondrial-targeted adeno-associated virus carrying either hND6T14484C or mitoc...

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Detalles Bibliográficos
Autores principales:	Yu, Hong, Sant, David W., Wang, Gaofeng, Guy, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545076/ https://www.ncbi.nlm.nih.gov/pubmed/33101779 http://dx.doi.org/10.1167/tvst.9.11.1

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