Mapping the native interaction surfaces of PREP1 with PBX1 by cross-linking mass-spectrometry and mutagenesis

Both onco-suppressor PREP1 and the oncogene MEIS1 bind to PBX1. This interaction stabilizes the two proteins and allows their translocation into the nucleus and thus their transcriptional activity. Here, we have combined cross-linking mass-spectrometry and systematic mutagenesis to detail the bindin...

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Detalles Bibliográficos
Autores principales: Bruckmann, Chiara, Tamburri, Simone, De Lorenzi, Valentina, Doti, Nunzianna, Monti, Alessandra, Mathiasen, Lisa, Cattaneo, Angela, Ruvo, Menotti, Bachi, Angela, Blasi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545097/
https://www.ncbi.nlm.nih.gov/pubmed/33033354
http://dx.doi.org/10.1038/s41598-020-74032-w

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