Vitamin D Deficiency has no Impact on PSA Reference Ranges in a General University Hospital – A Retrospective Analysis

BACKGROUND: Vitamin D deficiency has been linked to a higher risk of prostate cancer. We tested the hypothesis that vitamin D levels would have an impact on prostate specific antigen (PSA) levels. METHODS: From our laboratory database we selected 5136 male patients with simultaneously determined vitamin D and PSA levels. Subgroups of several age cohorts with different vitamin D levels were created and PSA 95 percentile values were assessed. The independent effect of vitamin D levels and age on PSA levels was determined with logistic regression. RESULTS: PSA levels increased with age, while no difference was identified in PSA levels in different vitamin D subgroups. CONCLUSION: Vitamin D levels do not have an effect on PSA. Hence, there is no need to adjust PSA reference ranges and threshold values to vitamin D levels during the process of decision making