Vitamin D Deficiency has no Impact on PSA Reference Ranges in a General University Hospital – A Retrospective Analysis

BACKGROUND: Vitamin D deficiency has been linked to a higher risk of prostate cancer. We tested the hypothesis that vitamin D levels would have an impact on prostate specific antigen (PSA) levels. METHODS: From our laboratory database we selected 5136 male patients with simultaneously determined vit...

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Autores principales: Tóth, Zoltán, Szalay, Balázs, Gyarmati, Béla, Jalal, Dlovan Ali, Vásárhelyi, Barna, Szabó, Tamás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Communications and Publications Division (CPD) of the IFCC 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545131/
https://www.ncbi.nlm.nih.gov/pubmed/33061877
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author Tóth, Zoltán
Szalay, Balázs
Gyarmati, Béla
Jalal, Dlovan Ali
Vásárhelyi, Barna
Szabó, Tamás
author_facet Tóth, Zoltán
Szalay, Balázs
Gyarmati, Béla
Jalal, Dlovan Ali
Vásárhelyi, Barna
Szabó, Tamás
author_sort Tóth, Zoltán
collection PubMed
description BACKGROUND: Vitamin D deficiency has been linked to a higher risk of prostate cancer. We tested the hypothesis that vitamin D levels would have an impact on prostate specific antigen (PSA) levels. METHODS: From our laboratory database we selected 5136 male patients with simultaneously determined vitamin D and PSA levels. Subgroups of several age cohorts with different vitamin D levels were created and PSA 95 percentile values were assessed. The independent effect of vitamin D levels and age on PSA levels was determined with logistic regression. RESULTS: PSA levels increased with age, while no difference was identified in PSA levels in different vitamin D subgroups. CONCLUSION: Vitamin D levels do not have an effect on PSA. Hence, there is no need to adjust PSA reference ranges and threshold values to vitamin D levels during the process of decision making
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spelling pubmed-75451312020-10-14 Vitamin D Deficiency has no Impact on PSA Reference Ranges in a General University Hospital – A Retrospective Analysis Tóth, Zoltán Szalay, Balázs Gyarmati, Béla Jalal, Dlovan Ali Vásárhelyi, Barna Szabó, Tamás EJIFCC Research Article BACKGROUND: Vitamin D deficiency has been linked to a higher risk of prostate cancer. We tested the hypothesis that vitamin D levels would have an impact on prostate specific antigen (PSA) levels. METHODS: From our laboratory database we selected 5136 male patients with simultaneously determined vitamin D and PSA levels. Subgroups of several age cohorts with different vitamin D levels were created and PSA 95 percentile values were assessed. The independent effect of vitamin D levels and age on PSA levels was determined with logistic regression. RESULTS: PSA levels increased with age, while no difference was identified in PSA levels in different vitamin D subgroups. CONCLUSION: Vitamin D levels do not have an effect on PSA. Hence, there is no need to adjust PSA reference ranges and threshold values to vitamin D levels during the process of decision making The Communications and Publications Division (CPD) of the IFCC 2020-09-29 /pmc/articles/PMC7545131/ /pubmed/33061877 Text en Copyright © 2020 International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This is a Platinum Open Access Journal distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tóth, Zoltán
Szalay, Balázs
Gyarmati, Béla
Jalal, Dlovan Ali
Vásárhelyi, Barna
Szabó, Tamás
Vitamin D Deficiency has no Impact on PSA Reference Ranges in a General University Hospital – A Retrospective Analysis
title Vitamin D Deficiency has no Impact on PSA Reference Ranges in a General University Hospital – A Retrospective Analysis
title_full Vitamin D Deficiency has no Impact on PSA Reference Ranges in a General University Hospital – A Retrospective Analysis
title_fullStr Vitamin D Deficiency has no Impact on PSA Reference Ranges in a General University Hospital – A Retrospective Analysis
title_full_unstemmed Vitamin D Deficiency has no Impact on PSA Reference Ranges in a General University Hospital – A Retrospective Analysis
title_short Vitamin D Deficiency has no Impact on PSA Reference Ranges in a General University Hospital – A Retrospective Analysis
title_sort vitamin d deficiency has no impact on psa reference ranges in a general university hospital – a retrospective analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545131/
https://www.ncbi.nlm.nih.gov/pubmed/33061877
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