High-throughput single-cell functional elucidation of neurodevelopmental disease–associated genes reveals convergent mechanisms altering neuronal differentiation

The overwhelming success of exome- and genome-wide association studies in discovering thousands of disease-associated genes necessitates developing novel high-throughput functional genomics approaches to elucidate the molecular mechanisms of these genes. Here, we have coupled multiplexed repression...

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Detalles Bibliográficos
Autores principales: Lalli, Matthew A., Avey, Denis, Dougherty, Joseph D., Milbrandt, Jeffrey, Mitra, Robi D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545139/
https://www.ncbi.nlm.nih.gov/pubmed/32887689
http://dx.doi.org/10.1101/gr.262295.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545139/
https://www.ncbi.nlm.nih.gov/pubmed/32887689
http://dx.doi.org/10.1101/gr.262295.120

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