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Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism

Hyper-virulent Streptococcus pneumoniae serotype 1 strains are endemic in Sub-Saharan Africa and frequently cause lethal meningitis outbreaks. It remains unknown whether genetic variation in serotype 1 strains modulates tropism into cerebrospinal fluid to cause central nervous system (CNS) infection...

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Detalles Bibliográficos
Autores principales:	Chaguza, Chrispin, Yang, Marie, Cornick, Jennifer E., du Plessis, Mignon, Gladstone, Rebecca A., Kwambana-Adams, Brenda A., Lo, Stephanie W., Ebruke, Chinelo, Tonkin-Hill, Gerry, Peno, Chikondi, Senghore, Madikay, Obaro, Stephen K., Ousmane, Sani, Pluschke, Gerd, Collard, Jean-Marc, Sigaùque, Betuel, French, Neil, Klugman, Keith P., Heyderman, Robert S., McGee, Lesley, Antonio, Martin, Breiman, Robert F., von Gottberg, Anne, Everett, Dean B., Kadioglu, Aras, Bentley, Stephen D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545184/ https://www.ncbi.nlm.nih.gov/pubmed/33033372 http://dx.doi.org/10.1038/s42003-020-01290-9

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