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Helicobacter pylori infection with atrophic gastritis: An independent risk factor for colorectal adenomas

BACKGROUND: The significance of Helicobacter pylori (H. pylori) infection and atrophic gastritis (AG) in the prevalence of colorectal adenomas has been examined in a limited number of studies. However, these studies reported disputed conclusions. AIM: To investigate whether H. pylori infection, AG,...

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Autores principales: Chen, Qin-Fen, Zhou, Xiao-Dong, Fang, Dan-Hong, Zhang, En-Guang, Lin, Chun-Jing, Feng, Xiao-Zhen, Wang, Na, Wu, Jian-Sheng, Wang, Dan, Lin, Wei-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545385/
https://www.ncbi.nlm.nih.gov/pubmed/33088161
http://dx.doi.org/10.3748/wjg.v26.i37.5682
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author Chen, Qin-Fen
Zhou, Xiao-Dong
Fang, Dan-Hong
Zhang, En-Guang
Lin, Chun-Jing
Feng, Xiao-Zhen
Wang, Na
Wu, Jian-Sheng
Wang, Dan
Lin, Wei-Hong
author_facet Chen, Qin-Fen
Zhou, Xiao-Dong
Fang, Dan-Hong
Zhang, En-Guang
Lin, Chun-Jing
Feng, Xiao-Zhen
Wang, Na
Wu, Jian-Sheng
Wang, Dan
Lin, Wei-Hong
author_sort Chen, Qin-Fen
collection PubMed
description BACKGROUND: The significance of Helicobacter pylori (H. pylori) infection and atrophic gastritis (AG) in the prevalence of colorectal adenomas has been examined in a limited number of studies. However, these studies reported disputed conclusions. AIM: To investigate whether H. pylori infection, AG, and H. pylori-related AG increase the risk of colorectal adenomas. METHODS: This retrospective cross-sectional study included 6018 health-check individuals. The relevant data for physical examination, laboratory testing, (13)C-urea breath testing, gastroscopy, colonoscopy and histopathological examination of gastric and colorectal biopsies were recorded. Univariate and multivariate logistic regression analyses were performed to determine the association between H. pylori-related AG and colorectal adenomas. RESULTS: Overall, 1012 subjects (16.8%) were diagnosed with colorectal adenomas, of whom 143 (2.4%) had advanced adenomas. Among the enrolled patients, the prevalence of H. pylori infection and AG was observed as 49.5% (2981/6018) and 10.0% (602/6018), respectively. Subjects with H. pylori infection had an elevated risk of colorectal adenomas (adjusted odds ratio [OR] of 1.220, 95% confidence interval (CI): 1.053-1.413, P = 0.008) but no increased risk of advance adenomas (adjusted OR = 1.303, 95%CI: 0.922-1.842, P = 0.134). AG was significantly correlated to an increased risk of colorectal adenomas (unadjusted OR = 1.668, 95%CI: 1.352-2.059, P < 0.001; adjusted OR = 1.237, 95%CI: 0.988-1.549, P = 0.064). H. pylori infection accompanied by AG was significantly associated with an increased risk of adenomas (adjusted OR = 1.491, 95%CI: 1.103-2.015, P = 0.009) and advanced adenomas (adjusted OR = 1.910, 95%CI: 1.022-3.572, P = 0.043). CONCLUSION: H. pylori-related AG was associated with a high risk of colorectal adenomas and advanced adenomas in Chinese individuals.
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spelling pubmed-75453852020-10-20 Helicobacter pylori infection with atrophic gastritis: An independent risk factor for colorectal adenomas Chen, Qin-Fen Zhou, Xiao-Dong Fang, Dan-Hong Zhang, En-Guang Lin, Chun-Jing Feng, Xiao-Zhen Wang, Na Wu, Jian-Sheng Wang, Dan Lin, Wei-Hong World J Gastroenterol Retrospective Study BACKGROUND: The significance of Helicobacter pylori (H. pylori) infection and atrophic gastritis (AG) in the prevalence of colorectal adenomas has been examined in a limited number of studies. However, these studies reported disputed conclusions. AIM: To investigate whether H. pylori infection, AG, and H. pylori-related AG increase the risk of colorectal adenomas. METHODS: This retrospective cross-sectional study included 6018 health-check individuals. The relevant data for physical examination, laboratory testing, (13)C-urea breath testing, gastroscopy, colonoscopy and histopathological examination of gastric and colorectal biopsies were recorded. Univariate and multivariate logistic regression analyses were performed to determine the association between H. pylori-related AG and colorectal adenomas. RESULTS: Overall, 1012 subjects (16.8%) were diagnosed with colorectal adenomas, of whom 143 (2.4%) had advanced adenomas. Among the enrolled patients, the prevalence of H. pylori infection and AG was observed as 49.5% (2981/6018) and 10.0% (602/6018), respectively. Subjects with H. pylori infection had an elevated risk of colorectal adenomas (adjusted odds ratio [OR] of 1.220, 95% confidence interval (CI): 1.053-1.413, P = 0.008) but no increased risk of advance adenomas (adjusted OR = 1.303, 95%CI: 0.922-1.842, P = 0.134). AG was significantly correlated to an increased risk of colorectal adenomas (unadjusted OR = 1.668, 95%CI: 1.352-2.059, P < 0.001; adjusted OR = 1.237, 95%CI: 0.988-1.549, P = 0.064). H. pylori infection accompanied by AG was significantly associated with an increased risk of adenomas (adjusted OR = 1.491, 95%CI: 1.103-2.015, P = 0.009) and advanced adenomas (adjusted OR = 1.910, 95%CI: 1.022-3.572, P = 0.043). CONCLUSION: H. pylori-related AG was associated with a high risk of colorectal adenomas and advanced adenomas in Chinese individuals. Baishideng Publishing Group Inc 2020-10-07 2020-10-07 /pmc/articles/PMC7545385/ /pubmed/33088161 http://dx.doi.org/10.3748/wjg.v26.i37.5682 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Retrospective Study
Chen, Qin-Fen
Zhou, Xiao-Dong
Fang, Dan-Hong
Zhang, En-Guang
Lin, Chun-Jing
Feng, Xiao-Zhen
Wang, Na
Wu, Jian-Sheng
Wang, Dan
Lin, Wei-Hong
Helicobacter pylori infection with atrophic gastritis: An independent risk factor for colorectal adenomas
title Helicobacter pylori infection with atrophic gastritis: An independent risk factor for colorectal adenomas
title_full Helicobacter pylori infection with atrophic gastritis: An independent risk factor for colorectal adenomas
title_fullStr Helicobacter pylori infection with atrophic gastritis: An independent risk factor for colorectal adenomas
title_full_unstemmed Helicobacter pylori infection with atrophic gastritis: An independent risk factor for colorectal adenomas
title_short Helicobacter pylori infection with atrophic gastritis: An independent risk factor for colorectal adenomas
title_sort helicobacter pylori infection with atrophic gastritis: an independent risk factor for colorectal adenomas
topic Retrospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545385/
https://www.ncbi.nlm.nih.gov/pubmed/33088161
http://dx.doi.org/10.3748/wjg.v26.i37.5682
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