Cargando…

Gukang Capsule Promotes Fracture Healing by Activating BMP/SMAD and Wnt/β-Catenin Signaling Pathways

BACKGROUND: Gukang capsule (GKC) is a traditional Chinese medicine formulation which has been used extensively in the clinical treatment of bone fractures. However, the mechanisms underlying its effects on fracture healing remain unclear. METHODS: In this study we used a rabbit radius fracture model...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Xue, Yang, Jian, Liu, Ting, Li, Jing, Lan, Yanyu, Wang, Yonglin, Wang, Aimin, Tian, Ye, Li, Yongjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545469/ https://www.ncbi.nlm.nih.gov/pubmed/33062020 http://dx.doi.org/10.1155/2020/7184502

Ejemplares similares

Albiflorin Promotes Osteoblast Differentiation and Healing of Rat Femoral Fractures Through Enhancing BMP-2/Smad and Wnt/β-Catenin Signaling
por: Kim, Jae-Hyun, et al.
Publicado: (2021)

Characterization of Wnt/β-catenin and BMP/Smad signaling pathways in an in vitro model of amyotrophic lateral sclerosis
por: Pinto, Cristina, et al.
Publicado: (2013)

Analysis of the potential biological mechanisms of Danyu Gukang Pill against osteonecrosis of the femoral head based on network pharmacology
por: Guo, Yongchang, et al.
Publicado: (2023)

Association of Bone Morphogenetic Protein (BMP)/Smad Signaling Pathway with Fracture Healing and Osteogenic Ability in Senile Osteoporotic Fracture in Humans and Rats
por: Liu, De-Bao, et al.
Publicado: (2018)

Deer antler extract promotes tibia fracture healing in mice by activating BMP-2/SMAD4 signaling pathway
por: Wang, Jianyu, et al.
Publicado: (2022)

Circ_SMAD4 promotes gastric carcinogenesis by activating wnt/β‐catenin pathway
por: Wang, Liyan, et al.
Publicado: (2021)

BMP-7 accelerates the differentiation of rabbit mesenchymal stem cells into cartilage through the Wnt/β-catenin pathway
por: Fu, Hong-Dan, et al.
Publicado: (2017)

Role of Wnt signaling in fracture healing
por: Xu, Huiyun, et al.
Publicado: (2014)

Cebpb Regulates Skeletal Stem Cell Osteogenic Differentiation and Fracture Healing via the WNT/β-Catenin Pathway
por: Wang, Jiansong, et al.
Publicado: (2022)

An appropriate Wnt/β-catenin expression level during the remodeling phase is required for improved bone fracture healing in mice
por: Bao, Quanwei, et al.
Publicado: (2017)

BMP9 promotes cutaneous wound healing by activating Smad1/5 signaling pathways and cytoskeleton remodeling
por: Chai, Peiwei, et al.
Publicado: (2021)

Activating Wnt/β-Catenin Signaling in Osteocytes Promotes Osteogenic Differentiation of BMSCs through BMP-7
por: Zhang, Yining, et al.
Publicado: (2022)

Smad1 stabilization and delocalization in response to the blockade of BMP activity
por: Li, Lili, et al.
Publicado: (2013)

Juglans regia L. extract promotes osteogenesis of human bone marrow mesenchymal stem cells through BMP2/Smad/Runx2 and Wnt/β-catenin pathways
por: Pang, Xianlun, et al.
Publicado: (2022)

Alterations of the MEK/ERK, BMP, and Wnt/β-catenin pathways detected in the blood of individuals with lymphatic malformations
por: Kim, Taehan, et al.
Publicado: (2019)

miR-1323 suppresses bone mesenchymal stromal cell osteogenesis and fracture healing via inhibiting BMP4/SMAD4 signaling
por: Xie, Hui, et al.
Publicado: (2020)

Ginsenoside Rg1 promotes osteogenic differentiation of rBMSCs and healing of rat tibial fractures through regulation of GR-dependent BMP-2/SMAD signaling
por: Gu, Yanqing, et al.
Publicado: (2016)

Activation of Wnt/β‐catenin signalling is required for TGF‐β/Smad2/3 signalling during myofibroblast proliferation
por: Xu, Liang, et al.
Publicado: (2017)

Wnt/β-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4
por: Fujimori, Sayumi, et al.
Publicado: (2010)

The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC
por: Voorneveld, P W, et al.
Publicado: (2015)

Tangshen Formula Improves Diabetes-Associated Myocardial Fibrosis by Inhibiting TGF-β/Smads and Wnt/β-Catenin Pathways
por: Hu, Lin, et al.
Publicado: (2021)

Oncogenic Herpesvirus KSHV Hijacks BMP-Smad1-Id Signaling to Promote Tumorigenesis
por: Liang, Deguang, et al.
Publicado: (2014)

Functionalized TiCu/TiCuN coating promotes osteoporotic fracture healing by upregulating the Wnt/β-catenin pathway
por: Tan, Jia, et al.
Publicado: (2022)

Effects of ergosteroside combined risedronate on fracture healing and BMP-2, BMP-7 and VEGF expression in rats
por: Xu, Xiaofeng, et al.
Publicado: (2021)

Icariin regulates miR-23a-3p-mediated osteogenic differentiation of BMSCs via BMP-2/Smad5/Runx2 and WNT/β-catenin pathways in osteonecrosis of the femoral head
por: Zhang, Xiao-yun, et al.
Publicado: (2021)

Icariin Augments Bone Formation and Reverses the Phenotypes of Osteoprotegerin-Deficient Mice through the Activation of Wnt/β-Catenin-BMP Signaling
por: Li, Xiao-Feng, et al.
Publicado: (2013)

TGF-β Prevents Phosphate-Induced Osteogenesis through Inhibition of BMP and Wnt/β-Catenin Pathways
por: Guerrero, Fátima, et al.
Publicado: (2014)

Correction: Oncogenic Herpesvirus KSHV Hijacks BMP-Smad1-Id Signaling to Promote Tumorigenesis
por: Liang, Deguang, et al.
Publicado: (2022)

Effects of BMP-2 compound with fibrin on osteoporotic vertebral fracture healing in rats
por: Ouyang, Xiao, et al.
Publicado: (2021)

Different effects of Wnt/β-catenin activation and PTH activation in adult and aged male mice metaphyseal fracture healing
por: Liu, Daocheng, et al.
Publicado: (2020)

Wnt + BMP = stem cell
por: LeBrasseur, Nicole
Publicado: (2005)

Msk is required for nuclear import of TGF-β/BMP-activated Smads
por: Xu, Lan, et al.
Publicado: (2007)

Osthole Promotes Bone Fracture Healing through Activation of BMP Signaling in Chondrocytes
por: Wang, Pinger, et al.
Publicado: (2017)

Lithium chloride promotes diabetic corneal epithelial wound healing by activating the Wnt/β‑catenin signaling pathway
por: Dan, Jing, et al.
Publicado: (2023)

Overexpression of BMP-7 reverses TGF-β1-induced epithelial-mesenchymal transition by attenuating the Wnt3/β-catenin and TGF-β1/Smad2/3 signaling pathways in HK-2 cells
por: Song, Yan, et al.
Publicado: (2020)

Myoneurin regulates BMP signaling by competing with Ppm1a for Smad binding
por: Yang, Shuyan, et al.
Publicado: (2022)

TGF‐β/Smad and Wnt/β‐catenin signaling pathways are involved in renal fibrosis and its therapies
por: Ying, Jialiang, et al.
Publicado: (2020)

Correction: TGF-β Prevents Phosphate-Induced Osteogenesis through Inhibition of BMP and Wnt/β-Catenin Pathways
Publicado: (2014)

Wnt/β-Catenin Regulates the Activity of Epiprofin/Sp6, SHH, FGF, and BMP to Coordinate the Stages of Odontogenesis
por: Aurrekoetxea, Maitane, et al.
Publicado: (2016)

2,4,5-Trimethoxyldalbergiquinol promotes osteoblastic differentiation and mineralization via the BMP and Wnt/β-catenin pathway
por: Yun, H-M, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_qsatt5gq4896agu92e1qtn2bo0