Inhibition of hypertrophy and improving chondrocyte differentiation by MMP-13 inhibitor small molecule encapsulated in alginate-chondroitin sulfate-platelet lysate hydrogel

BACKGROUND: Mesenchymal stem cells are a promising cell source for chondrogenic differentiation and have been widely used in several preclinical and clinical studies. However, they are prone to an unwanted differentiation process towards hypertrophy that limits their therapeutic efficacy. Matrix met...

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Detalles Bibliográficos
Autores principales: Jahangir, Shahrbanoo, Eglin, David, Pötter, Naomi, Khozaei Ravari, Mojtaba, Stoddart, Martin J., Samadikuchaksaraei, Ali, Alini, Mauro, Baghaban Eslaminejad, Mohammadreza, Safa, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545577/
https://www.ncbi.nlm.nih.gov/pubmed/33036643
http://dx.doi.org/10.1186/s13287-020-01930-1

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