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Associations of sleep characteristics with alpha‐synuclein in cerebrospinal fluid in older adults
OBJECTIVE: Sleep disorders as a preclinical symptom of synucleinopathies become more prevalent in older adults. Synucleinopathies might be caused by the abnormal aggregation of alpha‐synuclein in the brain, which was indicated by alpha‐synuclein levels in cerebrospinal fluid (CSF). We aimed to inves...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545588/ https://www.ncbi.nlm.nih.gov/pubmed/32949229 http://dx.doi.org/10.1002/acn3.51204 |
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author | Wang, Xiao‐Tong Liu, Feng‐Tao Bi, Yan‐Lin Shen, Xue‐Ning Xu, Wei Wang, Jian Tan, Lan Yu, Jin‐Tai |
author_facet | Wang, Xiao‐Tong Liu, Feng‐Tao Bi, Yan‐Lin Shen, Xue‐Ning Xu, Wei Wang, Jian Tan, Lan Yu, Jin‐Tai |
author_sort | Wang, Xiao‐Tong |
collection | PubMed |
description | OBJECTIVE: Sleep disorders as a preclinical symptom of synucleinopathies become more prevalent in older adults. Synucleinopathies might be caused by the abnormal aggregation of alpha‐synuclein in the brain, which was indicated by alpha‐synuclein levels in cerebrospinal fluid (CSF). We aimed to investigate associations of sleep characteristics with CSF alpha‐synuclein in older adults. METHODS: Our study recruited 536 cognitively intact individuals (aged between 40 and 90 years old) from the Chinese Alzheimer’s Biomarker and Lifestyle study. Sleep behaviors were assessed by Pittsburgh Sleep Quality Index and total alpha‐synuclein in CSF was measured by enzyme‐linked immune‐sorbent assay. We used multiple linear and non‐linear regression models for research. RESULTS: Significant non‐linear associations of CSF alpha‐synuclein with sleep time and duration were revealed. Individuals who went to bed and fell asleep too early or late tended to have lower CSF alpha‐synuclein (reflection point for time to bed and fall asleep were 10:26 p.m. and 10:40 p.m.). Lower CSF alpha‐synuclein was also observed in individuals with either excessive or insufficient sleep duration (reflection point: 7.24 hours). Besides, overall poor sleep quality (β = −0.0621; P = 0.0242), longer sleep latency (β = −0.0415; P = 0.0174) and lower sleep efficiency (β = 0.0036; P = 0.0017) showed linear associations with lower CSF alpha‐synuclein. Sleep disturbances and daytime dysfunction were not significantly associated with CSF alpha‐synuclein. INTERPRETATION: Poor sleep was associated with lower levels of CSF alpha‐synuclein in older adults, which may provide new insight into the prevention of synucleinopathies. |
format | Online Article Text |
id | pubmed-7545588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75455882020-10-16 Associations of sleep characteristics with alpha‐synuclein in cerebrospinal fluid in older adults Wang, Xiao‐Tong Liu, Feng‐Tao Bi, Yan‐Lin Shen, Xue‐Ning Xu, Wei Wang, Jian Tan, Lan Yu, Jin‐Tai Ann Clin Transl Neurol Research Articles OBJECTIVE: Sleep disorders as a preclinical symptom of synucleinopathies become more prevalent in older adults. Synucleinopathies might be caused by the abnormal aggregation of alpha‐synuclein in the brain, which was indicated by alpha‐synuclein levels in cerebrospinal fluid (CSF). We aimed to investigate associations of sleep characteristics with CSF alpha‐synuclein in older adults. METHODS: Our study recruited 536 cognitively intact individuals (aged between 40 and 90 years old) from the Chinese Alzheimer’s Biomarker and Lifestyle study. Sleep behaviors were assessed by Pittsburgh Sleep Quality Index and total alpha‐synuclein in CSF was measured by enzyme‐linked immune‐sorbent assay. We used multiple linear and non‐linear regression models for research. RESULTS: Significant non‐linear associations of CSF alpha‐synuclein with sleep time and duration were revealed. Individuals who went to bed and fell asleep too early or late tended to have lower CSF alpha‐synuclein (reflection point for time to bed and fall asleep were 10:26 p.m. and 10:40 p.m.). Lower CSF alpha‐synuclein was also observed in individuals with either excessive or insufficient sleep duration (reflection point: 7.24 hours). Besides, overall poor sleep quality (β = −0.0621; P = 0.0242), longer sleep latency (β = −0.0415; P = 0.0174) and lower sleep efficiency (β = 0.0036; P = 0.0017) showed linear associations with lower CSF alpha‐synuclein. Sleep disturbances and daytime dysfunction were not significantly associated with CSF alpha‐synuclein. INTERPRETATION: Poor sleep was associated with lower levels of CSF alpha‐synuclein in older adults, which may provide new insight into the prevention of synucleinopathies. John Wiley and Sons Inc. 2020-09-19 /pmc/articles/PMC7545588/ /pubmed/32949229 http://dx.doi.org/10.1002/acn3.51204 Text en © 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Wang, Xiao‐Tong Liu, Feng‐Tao Bi, Yan‐Lin Shen, Xue‐Ning Xu, Wei Wang, Jian Tan, Lan Yu, Jin‐Tai Associations of sleep characteristics with alpha‐synuclein in cerebrospinal fluid in older adults |
title | Associations of sleep characteristics with alpha‐synuclein in cerebrospinal fluid in older adults |
title_full | Associations of sleep characteristics with alpha‐synuclein in cerebrospinal fluid in older adults |
title_fullStr | Associations of sleep characteristics with alpha‐synuclein in cerebrospinal fluid in older adults |
title_full_unstemmed | Associations of sleep characteristics with alpha‐synuclein in cerebrospinal fluid in older adults |
title_short | Associations of sleep characteristics with alpha‐synuclein in cerebrospinal fluid in older adults |
title_sort | associations of sleep characteristics with alpha‐synuclein in cerebrospinal fluid in older adults |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545588/ https://www.ncbi.nlm.nih.gov/pubmed/32949229 http://dx.doi.org/10.1002/acn3.51204 |
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