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The Role of Inflammation in Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is a blinding eye disease which incidence gradually increases with age. Inflammation participates in AMD pathogenesis, including choroidal neovascularization and geographic atrophy. It is also a kind of self-protective regulation from injury for the eyes. In th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545698/ https://www.ncbi.nlm.nih.gov/pubmed/33061811 http://dx.doi.org/10.7150/ijbs.49890 |
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author | Tan, Wei Zou, Jingling Yoshida, Shigeo Jiang, Bing Zhou, Yedi |
author_facet | Tan, Wei Zou, Jingling Yoshida, Shigeo Jiang, Bing Zhou, Yedi |
author_sort | Tan, Wei |
collection | PubMed |
description | Age-related macular degeneration (AMD) is a blinding eye disease which incidence gradually increases with age. Inflammation participates in AMD pathogenesis, including choroidal neovascularization and geographic atrophy. It is also a kind of self-protective regulation from injury for the eyes. In this review, we described inflammation in AMD pathogenesis, summarized the roles played by inflammation-related cytokines, including pro-inflammatory and anti-inflammatory cytokines, as well as leukocytes (macrophages, dendritic cells, neutrophils, T lymphocytes and B lymphocytes) in the innate or adaptive immunity in AMD. Possible clinical applications such as potential diagnostic biomarkers and anti-inflammatory therapies were also discussed. This review overviews the inflammation as a target of novel effective therapies in treating AMD. |
format | Online Article Text |
id | pubmed-7545698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-75456982020-10-13 The Role of Inflammation in Age-Related Macular Degeneration Tan, Wei Zou, Jingling Yoshida, Shigeo Jiang, Bing Zhou, Yedi Int J Biol Sci Review Age-related macular degeneration (AMD) is a blinding eye disease which incidence gradually increases with age. Inflammation participates in AMD pathogenesis, including choroidal neovascularization and geographic atrophy. It is also a kind of self-protective regulation from injury for the eyes. In this review, we described inflammation in AMD pathogenesis, summarized the roles played by inflammation-related cytokines, including pro-inflammatory and anti-inflammatory cytokines, as well as leukocytes (macrophages, dendritic cells, neutrophils, T lymphocytes and B lymphocytes) in the innate or adaptive immunity in AMD. Possible clinical applications such as potential diagnostic biomarkers and anti-inflammatory therapies were also discussed. This review overviews the inflammation as a target of novel effective therapies in treating AMD. Ivyspring International Publisher 2020-09-23 /pmc/articles/PMC7545698/ /pubmed/33061811 http://dx.doi.org/10.7150/ijbs.49890 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Tan, Wei Zou, Jingling Yoshida, Shigeo Jiang, Bing Zhou, Yedi The Role of Inflammation in Age-Related Macular Degeneration |
title | The Role of Inflammation in Age-Related Macular Degeneration |
title_full | The Role of Inflammation in Age-Related Macular Degeneration |
title_fullStr | The Role of Inflammation in Age-Related Macular Degeneration |
title_full_unstemmed | The Role of Inflammation in Age-Related Macular Degeneration |
title_short | The Role of Inflammation in Age-Related Macular Degeneration |
title_sort | role of inflammation in age-related macular degeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545698/ https://www.ncbi.nlm.nih.gov/pubmed/33061811 http://dx.doi.org/10.7150/ijbs.49890 |
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