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An initial investigation of serum cytokine levels in patients with gadolinium retention
OBJECTIVE: To determine whether individuals with proposed gadolinium deposition disease (GDD) have elevated serum levels of pro-inflammatory and pro-fibrotic cytokines, and whether specific cytokines are correlated with certain symptoms. MATERIALS AND METHODS: Twenty-four participants recruited betw...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Colégio Brasileiro de Radiologia e Diagnóstico por Imagem
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545733/ https://www.ncbi.nlm.nih.gov/pubmed/33071374 http://dx.doi.org/10.1590/0100-3984.2019.0075 |
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author | Maecker, Holden T. Wang, Weiqi Rosenberg-Hasson, Yael Semelka, Richard C. Hickey, Joseph Koran, Lorrin M. |
author_facet | Maecker, Holden T. Wang, Weiqi Rosenberg-Hasson, Yael Semelka, Richard C. Hickey, Joseph Koran, Lorrin M. |
author_sort | Maecker, Holden T. |
collection | PubMed |
description | OBJECTIVE: To determine whether individuals with proposed gadolinium deposition disease (GDD) have elevated serum levels of pro-inflammatory and pro-fibrotic cytokines, and whether specific cytokines are correlated with certain symptoms. MATERIALS AND METHODS: Twenty-four participants recruited between May 2016 and June 2017 met GDD diagnostic criteria. The 64 control subjects provided serum samples before prophylactic flu vaccination. Serum cytokine levels were obtained with Luminex serum cytokine assay using eBiosciences/Affymetrix human 62-plex kits. Wilcoxon rank-sum tests were performed to assess the difference between the median fluorescence intensity values for the participants and the control group. Generalized linear models were built to evaluate the association between each cytokine of interest and selected participant symptoms. RESULTS: Serum levels of 14 cytokines, including nine pro-inflammatory cytokines, were statistically significantly elevated compared to controls (p ≤ 0.05). Hypotheses regarding pro-fibrotic cytokines and cytokine links to specific symptoms' intensity were not confirmed. CONCLUSION: The statistically significantly elevated cytokines may be markers of susceptibility to GDD or agents of symptom induction. These findings suggest that individuals developing symptoms characteristic of GDD after a contrast-assisted magnetic resonance imaging should be studied to investigate whether gadolinium retention and elevated cytokines may be related to their symptoms. |
format | Online Article Text |
id | pubmed-7545733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Colégio Brasileiro de Radiologia e Diagnóstico por Imagem |
record_format | MEDLINE/PubMed |
spelling | pubmed-75457332020-10-15 An initial investigation of serum cytokine levels in patients with gadolinium retention Maecker, Holden T. Wang, Weiqi Rosenberg-Hasson, Yael Semelka, Richard C. Hickey, Joseph Koran, Lorrin M. Radiol Bras Original Article OBJECTIVE: To determine whether individuals with proposed gadolinium deposition disease (GDD) have elevated serum levels of pro-inflammatory and pro-fibrotic cytokines, and whether specific cytokines are correlated with certain symptoms. MATERIALS AND METHODS: Twenty-four participants recruited between May 2016 and June 2017 met GDD diagnostic criteria. The 64 control subjects provided serum samples before prophylactic flu vaccination. Serum cytokine levels were obtained with Luminex serum cytokine assay using eBiosciences/Affymetrix human 62-plex kits. Wilcoxon rank-sum tests were performed to assess the difference between the median fluorescence intensity values for the participants and the control group. Generalized linear models were built to evaluate the association between each cytokine of interest and selected participant symptoms. RESULTS: Serum levels of 14 cytokines, including nine pro-inflammatory cytokines, were statistically significantly elevated compared to controls (p ≤ 0.05). Hypotheses regarding pro-fibrotic cytokines and cytokine links to specific symptoms' intensity were not confirmed. CONCLUSION: The statistically significantly elevated cytokines may be markers of susceptibility to GDD or agents of symptom induction. These findings suggest that individuals developing symptoms characteristic of GDD after a contrast-assisted magnetic resonance imaging should be studied to investigate whether gadolinium retention and elevated cytokines may be related to their symptoms. Colégio Brasileiro de Radiologia e Diagnóstico por Imagem 2020 /pmc/articles/PMC7545733/ /pubmed/33071374 http://dx.doi.org/10.1590/0100-3984.2019.0075 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Maecker, Holden T. Wang, Weiqi Rosenberg-Hasson, Yael Semelka, Richard C. Hickey, Joseph Koran, Lorrin M. An initial investigation of serum cytokine levels in patients with gadolinium retention |
title | An initial investigation of serum cytokine levels in patients with gadolinium retention |
title_full | An initial investigation of serum cytokine levels in patients with gadolinium retention |
title_fullStr | An initial investigation of serum cytokine levels in patients with gadolinium retention |
title_full_unstemmed | An initial investigation of serum cytokine levels in patients with gadolinium retention |
title_short | An initial investigation of serum cytokine levels in patients with gadolinium retention |
title_sort | initial investigation of serum cytokine levels in patients with gadolinium retention |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545733/ https://www.ncbi.nlm.nih.gov/pubmed/33071374 http://dx.doi.org/10.1590/0100-3984.2019.0075 |
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